Journal of Pharmaceutical Investigation
- Volume 24 Issue 2
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- Pages.57-65
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- 1994
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Dissolution Characteristics of Biphenyl Dimethyl Dicarboxylate from Solid Dispersions and Permeation through Rabbit Deuodenal Mucosa
고체분산체로부터 비페닐디메칠디카르복실레이트의 용출 특성 및 토끼의 십이지장 점막 투과
- Hyun, Jean (College of Pharmacy, Dongduck Women's University) ;
- Chun, In-Koo (College of Pharmacy, Dongduck Women's University)
- Published : 1994.06.20
Abstract
To increase the dissolution rate of practically insoluble biphenyl dimethyl dicarboxylate (DDB), various solid dispersions were prepared with water soluble carriers, such as povidone (PVP K-30), poloxamer 407, sodium deoxycholate (SDC) and polyethylene glycol (PEG) 6000, at drug to carrier ratios of 1:3, 1:5 and 1:10 (w/w) by solvent or fusion method. Dissolution test was performed by the paddle method. The dissolution rate of DDB tablets (25 mg) on market was found to be very low (11.44, 9.02 and 6.42% at pH 1.2, 4.0 and 6.5 after 120 min, respectively). However, dissolution rates of DDB from various solid dispersions were very fast and reached supersaturation within 10 min. DDB-PEG 6000 solid dispersion appeared to be better in enhancing the in vitro dissolution rate than others. Furthermore, the incorporation of DDB and phosphatidylcholine (PC) into
Keywords
- Biphenyl dimethyl dicarboxylate;
- Solid dispersion;
- Phosphatidylcholine;
- Bile salts;
- Cyclodextrins;
- Dissolution;
- Duodenal permeation