Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지

Effect of Ginsenosides on Bovine Liver Mitochondria Aldehyde Dehydrogenase Activity

인삼사포닌이 소의 간 미토콘드리아 ALDH 활성에 미치는 영향

  • Kim, Sun-Jin (Department of Biochemistry, College of Science, Yonsei University) ;
  • Lee, Hee-Bong (Department of Biochemistry, College of Science, Kangwon University) ;
  • Joo, Chung-No (Department of Biochemistry, College of Science, Yonsei University)
  • 김선진 (연세대학교 이과대학 생화학과) ;
  • 이희봉 (강원대학교 자연대학 생화학과) ;
  • 주충노 (연세대학교 이과대학 생화학과)
  • Published : 1994.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Effects of ginsenosides on the activities of bovine liver mitochondrial matrix ALDH and membrane bound ALDH were observed in vitro and it was found that both matrix and membrane bound ALDH were stimulated appreciably. The maximum activity for the matrix AkDH was found at the concentration of ginsenoside mixture being $10^{-7}$~$10^5$% and that for the membrane bound ALDH was at $10^{-6}$~$10^{-4}$%. It was also found that Km values of both ALDHS were lowered and their maximum velocity was increased. It was realized that the bovine liver mitochondrial matrix AkDH is Quite specific for the oxidation of low aliphatic aldehydes such as acetaldehyde and propionaldehyde. Therefore the increase of Vmax/Km value of the matrix ALDH in the presence of ginsenosides suggest that ginsenosides might stimulate the ALDH activity thereby resulting in the quick removal of harmful acetaldehyde from the liver to protect its toxicity.

Keywords