Panaxadiol and Panaxatriol from Panax ginseng C.A. Meyer Inhibit the Synthesis of Thromboxane $A_2$ in Adrenaline-Stimulated Human Platelet Aggregations

Panax ginseng C.A. Meyer의 PD와 PT는 아드레날린에 의해 유인된 사람 혈소판의 응집반응에서 Thromboxane $A_2$의 생성을 저해한다

In adrenaline-stimulated human platelets, panaxadiol (PD) and panaxatriol (PT) from Panax ginseng C.A. Meyer did not inhibit the $Ca^{2+}$-innux, but inhibited the formation of thromboxane $A_2$ and the platelet aggregations. It seems that PD and PT block a pathyway interconvefing arachidonic acids (20:4) to thromboxane $A_2$ (TX $A_2$), because the amount of $Ca^{2+}$ which phospholipase C or phospholipase $A_2$ requires to liberate 20 : 4 from membrane phospholipids was increased by PD and PT. These results mean that PH and PT have an antiplatelet effect by Inhibiting the formation of TX $A_2$.