Archives of Pharmacal Research
- Volume 17 Issue 3
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- Pages.145-149
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Hypotensive and Spasmolytic Activities of Crude Extract of Cyperus scariosus
- Gilani, Anwar H. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) ;
- Janbaz, K.H. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) ;
- Zaman, M. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) ;
- Lateef, A. (Department of Pharmacology, The Aga Khan University Medical College, Faculty of Health Sciences) ;
- Tariq, S.R. (Physiology, The Aga Khan University Medical College, Faculty of Health Sciences) ;
- Ahmad, H.R. (Physiology, The Aga Khan University Medical College, Faculty of Health Sciences)
- Published : 1994.06.01
Abstract
Intravenous administration of hydro-methanolic extract of Cyperus scariosus (3-10 mg/kg) produced hypotensive and bradcardiac effects. These effects remianed unaltered in atropinized animals indicating that cardiovascular effects of the plant extract are not medliated through activation of muscarinic receptors. In the in vitro studies, it suppressed the spontaneous contractions of guinea-pig paired atria, rat ulterus and rabbit jejunum in a concentration-dependent (0.1-1 mg/ml) manner. It also inhibited histanmine or acetylcholine-induced contractions of guinea-pig ieum indicating non-sepcific spasmolytic action. In rabbit aorta, it inhibited norepinephrine