Archives of Pharmacal Research
- 제17권4호
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- Pages.236-239
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Isoflavonoids on Mouse Lymphocyte Proliferation In Vitro
- Namgoong, Soon-Young (College of Pharmacy, Kangweon National University) ;
- Lee, Chang-Hee (Dept. of Chemistry, Kangweon National University) ;
- Lim, Hyun-Pyo (College of Pharmacy, Kangweon National University)
- 발행 : 1994.08.01
초록
The suppressive activity of isoflavonoids against lymphocyte proliferation in vitro was examined. Isoflabvonoid derivatives tested were isflavones isolated from Pueraia radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochainin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochainin A, daidzein, formononetin, genistein and 7-O-isopropylbiochaninl A showed the suppressive activity at
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