Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Computer Model for Fibrinogen Adsorption on Polyurethane Surface

  • Kim, Jong-Won (Institute of Biomedical Engineering, Seoul National University) ;
  • Shin, In-Sun (Dept. of Polymer Chemistry Lab., KIST) ;
  • Ryu, Gyu-Ha (Institute of Biomedical Engineering, Seoul National University) ;
  • Lee, Kyu-Back (Institute of Biomedical Engineering, Seoul National University) ;
  • Han, Dong-Keun (Dept. of Mathmatics Education, Korea National University of Education) ;
  • Kim, Young-Ha (Dept. of Mathmatics Education, Korea National University of Education) ;
  • Min, Byoung-Goo (Institute of Biomedical Engineering, Seoul National University)
  • Published : 1994.03.01
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Abstract

Protein adsorption on the polyurethane surface was modelled by a modified random sequential adsorption(RSA) process. In this model, polyurethane surface was modelled as a mixed domain of hydrophobic and hydrophilic parts which was implemented by a 2 dimensional $150{\times}150$ lattice in the computer. Protein adsorption was simulated using a small box which represents a particle of the protein, and polyurethane lattice by considering their hydrophobic interaction. In order to validate the model, we perfonned fibrinogen adsorption on polyurethane surface. Isotherms of the adsorbed protein were calculated and compared to the experimental data. The protein adsorption on the polyurethane surface could be well described using this computer model.

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References

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