한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제22권5호
  • /
  • Pages.447-452
  • /
  • 1994
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

신규의 Aminopeptidase M 저해제 MR-387A와 B를 생산하는 균주의 동정 및 저해제의 생산

Taxonobic Characteristics of Strain Producing MR-387A and B,New Inhibitors of Aminopeptidase M,and their Production

  • 정명철 (한국과학기술연구원 유전공학연구소) ;
  • 전효곤 (한국과학기술연구원 유전공학연구소) ;
  • 이호재 (한국과학기술연구원 유전공학연구소) ;
  • 고영희 (한국과학기술연구원 유전공학연구소)
  • 발행 : 1994.10.01
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초록

The strain SL-387 which produces new inhibitors of aminopeptidase M, MR-387A and B, was isolated from a soil sample. The strain has branched substrate mycelia, from which aerial hyphae develop in the form of open spirals. Spore surface is smooth. Melanoid and soluble pigme- nts were observed. The isolate contains LL-diaminopimelic acid in its cell wall hydrolysate, and has no pectinolytic activity. The strain SL-387 is closely related to Streptomyces griseoruber and S. naganishii, but is different from these strains in some cultural and physiological characteristics. This strain was, therefore, designated as Streptomyces sp. SL-387. The effects of several carbon and nitrogen sources on the production of the inhibitor were examined. Among them, glucose, galactose, mannose, and xylose were effective as a carbon source and soybean meal, soytone, fish meal, and gluten meal were effective as a nitrogen source. The maximum peak of the inhibitor production in jar fermentor was obtained on the fifth day of culture.

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참고문헌

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