Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effect of Puffer Fish Extract on the Acetaldehyde Metabolism in Rat

흰쥐에서 Acetaldehyde 대사에 미치는 복어추출물의 영향

  • Published : 1994.04.01
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Abstract

The present stduy was undertaken to investigate the possible effect of Puffer fish skin extract (Pf) on the heptic acetaldehyde metabolism . It was obsrved that PF markedly decreased the acetaldehyde levels in blood and liver. The activity of mitochondrial aldehyde dehydrogenase (Ald DH) increased by induction of acute intoxicatiion of alcohol (5 g/kg) was further increased through pretreatment with PF for 2 weeks. When PF was given to rat fed with 25% alcohol solution instead of water for 6 weeks. the activity of Ald DH in mitochondrial fraction decreased to about 28% compared with sucrose-treated group. But after pretreatemnt of PF, the activity was restored to the normal level. By the treatment with disulfiram (300 mg/kg, once a day for 3days) was restored to the control after the pretreatment with PF. And also mitochondrial Ald DH activity in vitro was not changed. All these observations suggest that reduction of acetaldehyde levels are partly due to increase activity of mitochondrial Ald DH. Therefore, the recovery from intoxication of acetaldehyde may be enhanced by treatment with PF.

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References

  1. Life Sciences v.15 Speculations on the biochemical pharmacology of ethanol Rahwan,R.G.
  2. Am. J. Pathol. v.48 The ultrastructure of fatty liver induced by prolonged ethanol ingestion Iseri,O.A.;Lieber,C.S.;Gottlieb,L.S.
  3. Biochim. Biophs. Acta v.161 The effect of acetaldehyde on mitochondrial function Cederbaum,A.I.;Lieber,C.S.;Rubin,E.
  4. J. Submicrosc. Cytol. v.12 Contractility of myofibroblasts during experimental liver cirrhosis Irle,C.;Kocher,O.;Gabbiani,G.
  5. Science v.189 Acetaldehyde oxidation by hepatic mitochondria : Decrease after chronic ethanol consumption Hasumura,Y.;Teschke,R.;Lieber,C.S.
  6. N. Engl. J. Med. v.292 High blood acetaldehyde levels following ethanol administration. : Differences between alcoholic and non-alcoholic sujects Korsten,M.A.;Matsuzaki,S.;Feinman,L.;Lieber,C.S.
  7. Biochem. Biophys. Res. Commun. v.100 Binding of acetaldehyde to rat liver microsomes : Enhancement after chronic alcohol consumption Nomura,F.;Lieber,C.S.
  8. 한국영양식량학회지 v.23 Alcohol 섭취 rat에서 alcohol의 대사효소계에 미치는 복어추출물의 효과 김동훈;김동수;최종원
  9. Bull. Japan. Soc. Sci. Fisher. v.35 Occurrence of ciguatoxin and ciguaterin in ciguatoxic fishea in the Ryuku and Amami island Hashimoto,Y.;Yasumoto,T.;Kamiya,H.;Yoshida,T.
  10. Gastroenterology v.98 Role of xantine oxidase in ethanol-induced lipid peroxidation in rats Kato,S.;Kawase,T.;Alderman,I.;Inatoma,N.;Lieber,C.S.
  11. Biochem. Pharmacol. v.24 Effects of ethanol on hepatic microsomal drug-metabolizing enzymes in the rat Liu,S.J.;Ramsey,R.K.;Fallon,H.J.
  12. Biochem. Pharmacol. v.26 Acetaldehyde occurrence in cerebrospinal fluid during ethanol level oxidation in rats and its dependence on the blood level and on dietary factors Pettersson,H.;Kiessling,K.H.
  13. Biochem. Pharmacol. v.25 The effect of inhibitors of alcohol metabolism upon the changes in the hepatic microsomal metabolism of foreign compounds produced by the acute administration of some alcohols to the rat Powis,G.;Grant,L.
  14. Manometric techniques Methods for the isolation of particulate components of the cell Schneider,W.C.;Umbreit,W.W.(ed.);Rurris,R.H.(ed.);Stauffer,J.F.(ed.)
  15. Biochem. Behav. v.13 Correlation between humane erythrocyte aldehyde dehydrogenase activity and sensitivity to alcohol Inoue,K.;Fukunaga,M.;Yamasawa,K.
  16. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J.
  17. Clin. Chem. v.33 Gas-chromatographic determination of ethanol in blood with 0.53mm fused-silica open tubular columns Penton,Z.
  18. Science v.170 Reduced nicotinamide-adenine dinucleotide phosphate oxidase, activity enhanced by ethanol consumption Lieber,C.S.;DeCarli,L.M.
  19. Hepatology v.4 Alcohol and the liver Lieber,C.S.
  20. Lancet v.i Cytosolic aldehyde dehydrogenase and alcoholism Agarwal,D.P.;Harada,S.;Goedde,H.W.;Schrappe,O.
  21. Arch. Biochem. Biophs. v.148 Aldehyde oxidation in rat liver mitochondria Smith,L.;Packer,L.
  22. New Engl. J. Med. v.288 Liver adaptaion and injury in alcoholism Steinmetz,P.R.
  23. Rev. Adv. Alcohol Drug Problems v.4 Acetaldehyde-its metabolism and role in the actions of alcohol Lindros,K.O.
  24. Lancet v.ⅱ Hepatic aldehyde dehydrogenase and alcoholism Jaenkos,W.J.;Cakebread,K.;Palmer,K.R.
  25. Annu. Rev. Pharmacol, Toxicol. v.21 The actions and metabolic fate of disulfiram Eneanya,D.L.;Bianchine,J.R.;Duran,D.O.;Andresen,B.D.
  26. Biochem. J. v.242 Inactivation of horse liver mitochondrial aldehyde dehydrogenase by disulfiram : Enhance that disulfiram is not active site-directed reagent Sanny,C.G.;Weiner,H.