Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Antimutagenic Effects of the Juice and Boiling Water Extract of houttuynia cordata Thunb

어성초즙 및 추출물의 항돌연변이 효과

  • Published : 1994.12.01
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Abstract

The inhibitory effects of the juice and boiling water extract of Houttuyina cordata Thunb., which has been known as a traditional folk antitumor agent, on the genotxicity induced by mutagens were investigated . For this purpose, Salmonella typhimurium TA98 and TA100, and the transheterozygous (mwh/+) third larvae of Drosophila melanogaster were used. The juice of fresh H. cordata 9JHC) and boiling H. cordata extract (BHC) showed antimutagenicities toared alfatoxin B₁ in S. typhimurium TA 98 and TA100. The JHC's inhibitory effect increased by 76% to 98% as the adding concentrations increased, and the BHC had a 86-97% inhibitory effect. however, in the case of N-methyl-N'-nitro-N nitrosoguanidine (MNNG), the JHC's inhibitory effect was 52-60% irrespectively of its concentrations and the BHC had a low inhibitory effect. The JHC and BHC slightly reduced the somatic chromosomal mutagenicity by MNNG in the wing hair spot test system (mwh/+) of D. melanogaster, which suggests that they can inhibit gene mutation , deletion and mitotic chromosomal recomgination.

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References

  1. 식물대도감 송주택
  2. 中樂大事典 v.上 小學館
  3. 경희대학교대학원 박사학위논문 수종의 한약물이 백서의 자연살해세포 활성에 미치는 영향 강윤호
  4. 경희한의대논문집 v.12 어성초수역의 항종양효과에 관한 연구 임사바나
  5. Antimutagenesis and anticarcinogenesis mechanisms Kada,T.;Inoue,T.;Ohta,T.;Shirasu,Y.
  6. Am. J. Clin. Nutr. v.41 Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population Colditw,G.A.;Branch,L.G.;Lipnick,R.J.;Willett,W.C.;Rosner,B.;Posner,B.M.;Hennekens,C.H.
  7. Carcinogenesis v.11 Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue Bresnick,E.;Brit,D.F.;Wolterman,K.;Wheeler,M.;Markin,R.S.
  8. Nutr. Cancer v.12 The effect of diets enriched in cabbage and collands on murine pulmonary metastasis Scholar,E.M.;Wolterman,K.;Birt,D.F.;Bresnick,E.
  9. Genetic toxicology of the diet Nutrition and cancer large scale cohort study Hirayama,T.;Knudsen,I.(ed.)
  10. Genetic carcinogenesis Salt and stomach Joosens,J.V.;Kesteloot,H.;Reed,P.I.(ed.);Hill,M.J.(ed.)
  11. Int. J. Epidemiol. v.15 Carrots, green vegetable and lung cancer : A case-control study Pisani,P.;Berrino,F.;Macaluso,M.;Pastorino,U.;Crosignani,P.;Baldasseroni,A.
  12. Int. J. Cancer v.32 Diet and colorectal cancer : A case-control study in Greece Manousos,O.;Day,N.E.;Trichopoulos,D.;Gerovassilis,F.;Tzonou,A.;Polychronopoulou,A.
  13. Mutat. Res. v.53 Anti-mutagenic action on vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate Kada,T.;Morita,K.;Inoue,T.
  14. Agric. Biol. Chem. v.52 Antimutagenicity of dialyzates of vegetables and fruits Shinohara,K.;Kuroki,S.;Miwa,M.;Kong,Z.L.;Hosoda,H.
  15. J. Agric. Food Chem. v.37 Isolation of compounds with antimutagenic activity from Savoy Chieftain cabbage Lawson,T.;Nunnally,J.;Walker,B.;Bresnick,E.;Wheeler,D.;Wheeler,M.
  16. Mutat. Res. v.202 Dietary inhibitors of mutagenesis and carcinogenesis Hayatsu,H.;Arimoto,S.;Negishi,T.
  17. Carcinogenesis v.10 Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1methyl-5H-pyrido[4,3-b]indole(Trp-P-2) Negishi,T.;Arimoto,S.;Nishizaki,C.;Hayatsu,H.
  18. Carcinogenesis v.12 Chemopreventive properties of chlorophyllin : inhibition of aflatoxin $B_1(AFB_1)$-DNA binding in vitro and anti-mutagenic activity againist $AFB_1$ and two heterocyclic amines in the Salmonella mutagenicity assay Dashwood,R.H.;Breinholt,V.;Bailey,G.S.
  19. Cancer Res. v.38 Inhibition of polycyclic aromatic hydrocarbon-induced necroplasia by naturally occuring indoles Wattenbery,L.W.;Loub,W.D.
  20. Mutat. Res. v.31 Methods for detecting carcinogens and mutagens with the Salmonella mammalian-microsome mutagenicity test Ames,B.N.;McCann,J.;Yamasaki,E.
  21. Mutat. Res. v.113 Revised methods for the Salmonella mutagenicity test Maron,D.M.;Ames,B.N.
  22. Mutat. Res. v.122 Genetic activity of the anticancer drug methotrexate in somatic cells of Drosophila melanogaster Wurgler,F.E.;Graf,U.;Frei,H.;Juon,H.
  23. Environ. Mutag. v.6 Somatic mutation and recombination test in Drosophila melanogaster Graf,U.;Wurgler,F.E.;Katz,A.J.;Frei,H.J.;Juon,H.;Hall,C.B.;Kale,P.G.
  24. Origins of human cancer Hsieh,D.D.H.;Wong,J.J.Z.A.;Michas,C.;Ruebner,B.H.;Haiatt,H.H.(ed.);Watson,J.D.(ed.);Winsten,J.A.(ed.)
  25. Mutation Research Auerbach,C.
  26. Ann. Rev. Genet. v.17 Mutational specificity in bacteria Miller,J.H.
  27. Kor. J. Genetics v.14 Somatic mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine detected by Drosophila somatic gene and chromosome mutation assaying system Choi,Y.H.;Yoo,M.A.;Lee,W.H.
  28. The genetics and biology of Drosophila v.1C Mitotic recombination Becker,H.J.;Ashburner,M.(ed.);Novitski,E.(ed.)
  29. Wilhelm Roux's Arch. Biol. v.183 The effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster Haynie,J.L.;Bryant,P.J.
  30. Pusan Natl. Univ. J. Sci. v.42 Variation in hypersensitivities of repair-defective strain mei-9 mei-41 of Drosophila melanogaster to somatic induction of chromosome mutations and killing with IQ and Trp-P-2 Yoo,M.A.
  31. Mutat. Res. v.122 Enhanced susceptibility of a transposable-element-bearing strain of Drosophila melanogaster to somatic eye-color mutations by ethyl nitrosourea, methyl nitrosourea and X-rays Ryo,H.;Kondo,S.;Rasmuson,B.
  32. Genetics v.110 Comparison of somatic reversions between the ivory allele and transposon-caused mutant alleles at the white locus of Drosophila melanogaster after treatment with X-ray and ethyl methanesulfonate Ryo,H.;Yoo,M.A.;Fujikawa,K.;Kondo,S.
  33. 한국영양식량학회지 v.21 들깻잎에서의 동정된 항돌연변이 물질 이경임;이숙희;박건영;김정옥
  34. Environ. Mutag. Carcin. v.13 Effects of phytol on the mutagenicity of UV and EMS in Salmonella and Drosophila mutation assaying system Choi,Y.H.;Ahn,S.J.;Park,K.Y.;Yoo,M.A.;Lee,W.H.
  35. 대한약학회지 v.38 Drosophila에서 인삼 및 단삼 추출물이 MNNG의 돌연변이원성에 미치는 영향 최영현;정해영;유미애;이원호
  36. Environ. Mutag. Carcin. v.7 Relationships between LET and RBE of ionizing radiation in the induction of somatic mutations of Drosophila melanogaster Yoo,M.A.;Chung,W.H.;Lee,W.H.