Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

EFFECT OF GROWTH FACTORS ON THE MITOGENIC ACTIVITY OF PERIODONTAL LIGAMENT CELLS

수종의 growth factor가 치주인대세포의 유사분열에 미치는 영향

  • Bak, Jung-Gyu (Dept. of Periodontology, College of Dentistry, Pusan National University) ;
  • Kim, Sung-Jo (Dept. of Periodontology, College of Dentistry, Pusan National University) ;
  • Choi, Jeom-Il (Dept. of Periodontology, College of Dentistry, Pusan National University)
  • 박정규 (부산대학교 치과대학 치주과학교실) ;
  • 김성조 (부산대학교 치과대학 치주과학교실) ;
  • 최점일 (부산대학교 치과대학 치주과학교실)
  • Published : 1994.11.30
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Abstract

The purpose of the present study was to evaluate the effect of platelet - derived growth factor(PDGF) - BB and insulin - like growth factor(IGF) - 1, Centella Asiatica, and Zea Mays L. on the mitogenic activity of PDL cells from healthy and RPP patients. Combination of PDGF - BB and IGF - 1, Centella Asiatica, and Zea Mays L. were treated on PDL cells and the mitogenic effects were meaured by quantitative assay of methyl - $^3H$ - thymidine incorporation during DNA synthesis. Combination of PDGF - BB and IGF - 1 enhenced the mitogenic effects of both healthy and RPP PDL cells, however, the effect was less pronounced on RPP PDL cells. In cases of Centella Asiatica and Zea Mays L., no mitogenic effect on healthy PDL cells could be noticed.

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