Korean Journal of Veterinary Research (대한수의학회지)
- Volume 34 Issue 1
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- Pages.37-47
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- 1994
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effects of GS-386 on the calcium current in rabbit atrial myocytes
GS-386이 단일 심근 세포의 Ca2+ 전류에 미치는 효과
- Park, Choon-ok (Department of Physiology and the Institute of Cardiovascular Research, College of Medicine, Gyeongsang National University) ;
- Chang, Kyeong-jae (Department of Physiology and the Institute of Cardiovascular Research, College of Medicine, Gyeongsang National University) ;
- Kim, Yang-mi (Department of Physiology and the Institute of Cardiovascular Research, College of Medicine, Gyeongsang National University) ;
- Haan, Jae-hee (Department of Physiology and the Institute of Cardiovascular Research, College of Medicine, Gyeongsang National University) ;
- Hong, Seong-geun (Department of Physiology and the Institute of Cardiovascular Research, College of Medicine, Gyeongsang National University)
- 박춘옥 (경상대학교 의과대학 생리학교실, 심혈관연구소) ;
- 장경재 (경상대학교 의과대학 생리학교실, 심혈관연구소) ;
- 김양미 (경상대학교 의과대학 생리학교실, 심혈관연구소) ;
- 한재희 (경상대학교 의과대학 생리학교실, 심혈관연구소) ;
- 홍성근 (경상대학교 의과대학 생리학교실, 심혈관연구소)
- Received : 1993.10.18
- Published : 1994.01.31
Abstract
The effects of the novel compound GS-386 on the calcium current were investigated in rabbit atrial myocytes. The calcium current was recorded during various depolarizations of 200 ms duration from a holding potential of -40 mV using the whole cell patch clamp technique. The calcium current was activated from -30 mV, reached maximum amplitude at +10 mV and almost disappeared at +50 mV. Superfusion of GS-386 led to a reduction of the calcium current amplitude dose-dependently and