Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Effect of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P on isolated renal artery of rabbit

토끼 적출 신동맥에 대한 calcitonin gene-related peptide, vasoactive intestinal peptide 및 substance P의 효과

  • Kim, Joo-heon (College of Veterinary Medicine Gyeongsang National University) ;
  • Shim, Cheol-soo (Eastern Branch Gyeongnam Animal Health Institute) ;
  • Park, Sang-eun (Central Branch Gyeongnam Animal Health Institute)
  • 김주헌 (경상대학교 수의과대학) ;
  • 심철수 (경상남도 가축위생시험소 동부지소) ;
  • 박상은 (경상남도 가축위생시험소 중부지소)
  • Received : 1994.08.17
  • Published : 1994.10.01
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Abstract

To elucidate the effect of calcitonin gene-related peptide(CGRP), vasoactive intestinal peptide(VIP) and substance P was investigated with perivascular nerve stimulation and treatment of peptides from polygraph in the isolated renal artery of rabbit. 1. The neurogenic contraction induced by perivascular nerve stimulation was the frequency-dependent manner(264 Hz) in the isolated renal artery of rabbit. 2. CGRP and VIP caused the relaxation on the precontraction with noradrenaline($10{\mu}m$) on the presence and absence of endothelium in the isolated renal artery of rabbit. 3. Substance P caused the endothelium-dependent relaxation on the precontraction with noradrenaline($10{\mu}m$) in the isolated renal artery of rabbit. 4. CGRP and VIP inhibited the neurogenic contraction by the perivascular nerve stimulation(0.3 ms, 80 V, 50 Hz, 1 sec) on the absence and presence of endothelium in the isolated renal artery of rabbit. 5. Substance P inhibited on the neurogenic contraction by the perivascular nerve stimulation with the endothelium-dependent in the isolated renal artery of rabbit.

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Acknowledgement

Supported by : 한국학술진흥재단