Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Amiodarone-Induced Pulmonary Toxicity

Amiodarone에 의해 유발된 폐 독성 1예

  • Shim, Jae-Jeong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Sang-Hwa (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Yoo, Jae-Myung (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Suh, Hong-Suk (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Oh, Dong-Joo (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Joh, Jae-Youn (Department of Internal Medicine, College of Medicine, Korea University) ;
  • In, Kwang-Ho (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Yoo, Se-Hwa (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kang, Kyung-Ho (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kang, Eun-Young (Department of Radiology, College of Medicine, Korea University) ;
  • Chae, Yang-Suk (Department of Pathology, College of Medicine, Korea University)
  • 심재정 (고려대학교 의과대학교 내과학교실) ;
  • 이상화 (고려대학교 의과대학교 내과학교실) ;
  • 유재명 (고려대학교 의과대학교 내과학교실) ;
  • 서홍석 (고려대학교 의과대학교 내과학교실) ;
  • 오동주 (고려대학교 의과대학교 내과학교실) ;
  • 조재연 (고려대학교 의과대학교 내과학교실) ;
  • 인광호 (고려대학교 의과대학교 내과학교실) ;
  • 유세화 (고려대학교 의과대학교 내과학교실) ;
  • 강경호 (고려대학교 의과대학교 내과학교실) ;
  • 강은영 (고려대학교 의과대학교 방사선과학교실) ;
  • 채양석 (고려대학교 의과대학교 해부병리학교실)
  • Published : 1994.02.28
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Abstract

Amiodarone is a potent antiarrythmic agent used in the treatment of refractory tachyarrythmias and premature ventricular contractions. Amiodarone may be responsible for the frequent and various side effects including corneal deposits, abnormal liver function test, hyperthyriodism or hypothyroidism, bluish discoloration of the skin, neuropathies, and the others. However, pulmonary toxicity is most serious adverse reaction limiting the clinical efficacy. Rescently, we experienced a case of pulmonary toxicity induced by low dose 10-month amiodarone treatment for atrial fibrilation with rapid ventricular response. Lung biopsy reveals interstitial inflammation, fibrosis, hyperplasia of pneumocytes, and foamy macrophages. Respiratory symptoms and abnormal chest X-ray findings were nearly complete cleared after using steroid and withdrawal of amiodarone. We report a case of amiodarone-induced pulmonary toxicity with literature review.

저자들은 만성 심방성 세동환자에서 amiodarone 저용량으로 사용하던 중 폐독성이 발생된 1예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

Keywords