Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Dopamine ${\beta}-Hydroxylase$ Inhibitory Activity of Medicinal Plants

식물성 생약의 도파민 베타 수산화효소에 대한 저해활성

  • Tae, Dong-Nyen (Natural Products Research Institute, Seoul National University) ;
  • Hwang, Keum-Hee (Natural Products Research Institute, Seoul National University) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University)
  • 태동년 (서울대학교 천연물과학연구소) ;
  • 황금희 (서울대학교 천연물과학연구소) ;
  • 한용남 (서울대학교 천연물과학연구소)
  • Published : 1995.03.30
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Abstract

Dopamine ${\beta}-hydroxylase$ (DBH) catalyses the enzymatic reaction of dopamine to norepinephrine. For the purpose of isolating DBH inhibitors from natural resources, thirty one kinds of medicinal plants were screened by tracing the inhibitory activities against bovine adrenal DBH, utilizing tyramine as a substrate. Among the crude drugs tested, leaves of Lactuca sativa L., Gardeniae Fructus, Magnoliae Flos and Scutellariae Radix showed potent enzyme inhibitory activities against DBH.

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