Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Serum Cholesterol Lowering Effects and Triterpenoids of the Herbs of Lactuca indica

왕고들빼기의 혈청 콜레스테롤 저하효과 및 트리테르페노이드 성분

  • Park, Hee-Juhn (College of Life Science & Natural Resources, Sangji University) ;
  • Lee, Myung-Sun (College of Life Science & Natural Resources, Sangji University) ;
  • Lee, Eun (College of Life Science & Natural Resources, Sangji University) ;
  • Choi, Moo-Young (College of Natural Science & Engeneering, Sangji University) ;
  • Cha, Bae-Chun (College of Life Science & Natural Resources, Sangji University) ;
  • Jung, Won-Tae (Central Research Institute, Il-Yang Pharm. Co.) ;
  • Young, Han-Suk (College of Pharmacy, Pusan National University)
  • 박희준 (상지대학교 생명자원과학대학) ;
  • 이명선 (상지대학교 생명자원과학대학) ;
  • 이은 (상지대학교 생명자원과학대학) ;
  • 최무영 (상지대학교 이공과대학) ;
  • 차배천 (상지대학교 생명자원과학대학) ;
  • 정원태 (일양약품 중앙연구소) ;
  • 양한석 (부산대학교 약학대학)
  • Published : 1995.03.30
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Abstract

A methanol extract of the herbs of Lactuca indica L. effectively decreased the serum levels of total cholesterol and LDL-cholesterol when orally administered with diet. On fractionation of the extract, a chloroform-soluble fraction showed the similar effects with the methanol extract. Chromatographic separation afforded a mixture of triterpene alcohols and their acyl derivatives. A mixture of triterpene alcohols were identified as ${\beta}-amyrin$, ${\alpha}-amyrin$, lupeol, pseudotaraxasterol, taraxasterol and germanicol on the basis of spectroscopic methods. The acyl moieties in the corresponding acyl mixture were characterized as acetates and palmitates, respectively. And three kinds of sterol such as ${\beta}-sitossterol$, compesterol and stigmasterol were isolated as a mixture state.

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