Korean Journal of Pharmacognosy (생약학회지)
- Volume 26 Issue 1
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- Pages.74-77
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- 1995
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Antithrombotic Effect of the BuOH Soluble Fraction of Angelica dahurica Root
백지 BuOH 가용분획의 항혈전 활성에 관한 연구
- Kim, Chang-Min (College of Pharmacy, Kwang Won National University) ;
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Kwon, Yong-Soo
(College of Pharmacy, Kwang Won National University)
;
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YunChoi, Hye-Sook
(Natural Products Research Institute, Seoul National University)
- Published : 1995.03.30
Abstract
Several coumarins isolated from Angelica sp. were described to show inhibitory effects against human platelet aggregation. The anti-thrombotic and anti-platelet potential was evaluated, in this paper, with the BuOH soluble fraction of Angelica dahurica root. The BuOH fraction was divided into five subfractions fr. A - E and tested in the mouse model of thrombosis. Survival was enhanced to 35% with fr. A or fr. E treated (500 mg/Kg, p.o.) group of mice compared with 5% survival of the control group. However, none of the 8 coumarin glycosides obtained from fr. A, at the conc. of 0.5 mg/ml, showed inhibitory effects against rat platelet aggregation induced by ADP or collagen.