Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Anticancer Effect of Hydrophobic Protein Fraction from Red Ginseng by Clonogenic Assay

Clonogenic Assay에 의한 홍삼 소수성단백질 분획의 항암효과

  • Kim, Chang-Han (Molecular & Bioscience Laboratory, Animal Resources Research Center, Kon-Kuk University) ;
  • Lee, Myung-Sub (Molecular & Bioscience Laboratory, Animal Resources Research Center, Kon-Kuk University) ;
  • Lee, Kyung-Ho (Molecular & Bioscience Laboratory, Animal Resources Research Center, Kon-Kuk University)
  • 김창한 (건국대학교 동물자원연구센터 분자세포생물학교실) ;
  • 이명섭 (건국대학교 동물자원연구센터 분자세포생물학교실) ;
  • 이경호 (건국대학교 동물자원연구센터 분자세포생물학교실)
  • Published : 1995.04.01
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Abstract

We established the model of clonogenic assay with cancer cell lines such as SW-156(kidney), SNU-5(stomach), Hep G2(liver), and WiDr(colon), and we investigated anticancer effect of hydrophobic protein fraction(N-fraction) from Korea red ginseng by using this model. The results of clonogenic assay showed that N-fraction had anticancer activity against SNU-5 above 100 $0.2\mu\textrm{g}$/ml concentration, and did not exhibit anticancer activity against cell lines such as SW-156, WiDr, and Hep G2 up to 1,000 $\mu\textrm{g}$/ml concentration. This result suggests that N-fraction has specially anti-stomach cancerous effect.

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