YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-stress Effects of Ursodexycholic Acid on the Restraint Stress in Rats

흰쥐에서 구속스트레스에 대한 우루소데옥시콜린산의 항스트레스 효과

  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 염제호 (성균관대학교 약학대학) ;
  • 유은주 (㈜ 대웅제약 중앙연구소) ;
  • 임승욱 (㈜ 대웅제약 중앙연구소) ;
  • 장병수 (㈜ 대웅제약 중앙연구소) ;
  • 김영만 (㈜ 대웅제약 중앙연구소) ;
  • 유영효 (㈜ 대웅제약 중앙연구소) ;
  • 박명환 (㈜ 대웅제약 중앙연구소)
  • Published : 1995.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Effects of restraint stress and its modulations by ursodeoxycholic acid(UDCA) were evaluated on some biochemical and biophysical parameters in rats. Restraint stress induced elevations in blood alkaline phosphatase (ALP). cholesterol (CHOL), aspartate transaminase (GOT), alanine transaminase (GPT), lactate dehydrogenase (LDH) levels. It was also caused adrenal hypertrophy, decrease in weight of spleen and contents of ascorbic acid in stressed rats. As a results, stress indicators such as spleen, ascorbic acid, GOT, GPT, LDH were fastly changed after imposing stress, but those such as ALP, CHOL, adrenal were induced relatively later. UDCA was tested if it has an inhibitory effect against 18-hr restraint induced stress. UDCA lowered ALP, CHOL, LDH level and also effectively elevated the ascorbic acid contents in 25 mg/kg dosage of UDCA. In organ weights. the restraint stress induced increases in spleen and adrenal were attenuated by UDCA in 50 mg/kg dosage. However. stress-induced GOT and GPT levels were unaffected by UDCA.

Keywords

References

  1. The stress of life Selye,H.
  2. 전통약물로부터 신약개발 연구법 서울대학교 천연물과학연구소
  3. Lloydia v.32 Pharmacological investigation of glycosides from Gingseng and Eleutherococcus Brekhman,I.I.
  4. Indian J. Exp. Biol. v.30 Mechanism of anti-stress activity of Linn, eugenol and in experimental animals Sen,P.;Maiti,P.C.;Ray,A.
  5. Life Sci. v.31 Effect of ursodeoxycholic aid on the bile flow in the rat Kitani,K.;Kanai,S.
  6. Drugs v.27 Ursodeoxycholic acid: A review of its pharmacological properties and therapeutic efficacy Ward,A.;Brogden,R.N.;Heel,R.C.;Speight,T.M.;Avery,G.S.
  7. Gastroenterology v.95 Effect of ursodesoxycholic acid on biliary lipid coupling and on cholesterol absorption during fasting and eating in subjects with cholesterol gallstones Lanzini,A.;Northfield,T.C.
  8. Surgery v.105 Regulation of gallbladder ion transport(role of bile lipids) Roslyn,J.J.;Abedin,M.Z.;Strichartz,S.D.;Abdou,M.S.;Palant,C.E.
  9. Nippon shokakibyo Gakkai Zasshi(JAPAN) v.86 no.10 Effect of ursodeoxycholic acid on water immersion restraint stress ulcer of rats Kawamura,T.;Koizumi,F.;Ishimori,A.
  10. Clin. Chem. v.12 A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase Bowers,G.N.;McComb,R.B.
  11. Ann. Clin. Biochem. v.10 An investigation of the determination of serum cholesterol by an enzymatic method Flegg,H.M.
  12. Clin. Chem. v.24 Revised IFCC method for aspartate aminotransferase Saris,N.E.
  13. Proc. Soc. Exp. Biol. Med. v.91 Serum glutamic pyruvic transaminase in cardiac and hepatic disease Wroblewski,F.;LaDue,J.S.
  14. Clin. Chem. v.14 Optimum reaction conditions for human lactate dehydrogenase isoenzymes as they affect total lactate dehydrogenase activity Gay,R.J.;McComb,R.B.;Bowers,G.N.
  15. Kor. J. Pharmacog. v.10 인삼의 항스트레스 작용에 대한 연구 김낙두(외)
  16. Gastroenterology v.5 Shay,H.;Komakov,S.A.F.F.;Meraze,D.;Gruentfein,M.;Siplet,H.
  17. 생리학 차영선
  18. Stress Cox,T.
  19. Endocrinology v.87 Adrenal and lung catecholamines in rats during adaptation to repeated in mobilization stress Kvetnansky,R.;Mikulaj,L.
  20. Am. J. Physiol. v.221 Catecholamine and metabolite excretion in coldstressed immunosympathetonized rats Shum,A.;Johnson,G.E.;Flattery,K.V.