Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Intravenous and Oral Toxicity of DWC-751 in Rats and Mice

랫드 및 마우스에서 DWC-751의 급성정맥 및 경구 독성시험

  • 김재현 (국립보건안전연구원 독성부) ;
  • 박창원 (국립보건안전연구원 독성부) ;
  • 강진석 (대웅제약 중앙연구소) ;
  • 유영효 (대웅제약 중앙연구소) ;
  • 박정식 (국립보건안전연구원 독성부)
  • Published : 1995.06.01
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Abstract

Single intravenous and oral administration to SD rats and ICR mice of both sexes were performed to investigate the acute toxicity of DWC-751, a new parenteral cephalosporin. $LD_50$ values for ICR mice and SD rats administered intravenously with DWC-751 were as follows; 1151.1 mg/kg (male SD rat), 1183.5 mg/kg (female SD rat), 2698.1 mg/kg (male ICR mouse), 2833.0 mg/kg (female ICR mouse). It is suggested that $LD_50$ values in rats and mice of both sexes would be 5000 mg/kg in oral route. Major general symptoms induced by injection intravenously with DWC-751 are decreased motor activity, increased respiratory rate, tremor and convulsion. In oral route, piloerection and soft stool are observed to 4 day after administration. No significant body weight changes were observed at any level in the groups administered with DWC-751. The gross finding of rats administered intravenously was observed cecum distension.

Keywords

References

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  5. 국립보건안전연구원 예규 제 10호 의약품등의 독성시험 기준 국립보건안전연구원
  6. β-lactam antibiotics 日泰;淸水喜八郞