Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Toxicity of HRccine (HFRS virus vaccine) in Rats and Rabbits

HRccine(HFRS-virus vaccine)의 급성독성

  • 임동문 (제일제당(주) 종합연구소) ;
  • 백영옥 (제일제당(주) 종합연구소) ;
  • 김달현 (제일제당(주) 종합연구소) ;
  • 박관하 (제일제당(주) 종합연구소) ;
  • 조정식 (제일제당(주) 종합연구소) ;
  • 이영순 (서울대학교 수의과대학)
  • Published : 1995.06.01
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Abstract

HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body weight changes, clinical signs and autopsy findings between all treated groups and control group in both animals. Therefore, it was concluded that HRccine is a very safe substance.

Keywords

References

  1. Vaccine v.6 Development of inactivated vaccine against virus causing hemorrhagic fever with renal syndrome Koichi Yamanishi(et al.)
  2. 국립보건안전연구원 고시 제 94-3호 의약품등의 독성 시험 기준 국립 보건 안전 연구원