Effect of Dietary Hot Red Pepper Powder on Humoral Immune Response in Rat

고춧가루 첨가 식이가 흰주의 체액성 면역기능에 미치는 영향

  • Published : 1995.12.01

Abstract

Hot red pepper(Capsicum annum L.) has been extensively used as a spicy food additive and preservative in Korea. In this study, we investigated the effect of dietary hot red pepper powder on humoral immune response in rats. Sprague-Dawley rats were divided into 4 groups and fed experimental diets containing 0, 2, 5, 10% hot red pepper powder for 27 days. All groups were immunized with sheep red blood cells. In order to measure the immune response, plaque-forming cell number, agglutination titer, and serum antibody level were measured. Tissue ascorbic acid contents were also determined by high-performance liquid chromatogrphy. There was an increased plaque-forming cell number, agglutination titer, and serum IgG level in the groups supplemented with hot red pepper powder as compared to control. Tissure ascorbic acid contents in the hot pepper powder supplemented group were higher than those of control. The results suggest that the dietary hot red pepper powder enhances humoral immune response in rats, indicating that the hot pepper contains biological response modifier.

고추가루 첨가 식이가 체액성 면역기능에 미치는 영향을 조사하였다. 실험동무로 흰쥐를 사용하여 대조군과 2%, 5%, 10% 고추가루 첨가 식이군을 설정한 후 27일간 실험식이로 사육하였다. 실험종료 10일 전에 각군의 흰쥐를 면양적혈구로 세차례 면역시킨 후 항체생성 세포수 및 혈청 중 항체 농도 등 체액성 면역기능을 중심으로 조사하였다. 그 결과, 대조군에 비해 고추가루 첨가 식이군의 항체 생성 세포수, 적혈구 응집반응 및 혈청중 항체 농도가 높은 것으로 나타났으며, 또한 이때 고추가루 첨가식이군의 각 장기조직 중 AsA 함량은 대조군에 비해 높은 것으로 나타났다. 이들 결과로 보아, 고추성분은 체액성 면역기능의 활성화에 기여하는 물질을 함유하고 있을 뿐만이 아니라, AsA의 공급효과가 뛰어난 것이 확인되었다.

Keywords

References

  1. 한국농화학회지 v.20 고추의 색도측정과 품질과의 관계 박상기;김재한
  2. Agric. Biol. Chem. v.51 Enhancement by capsaicin of energy metabolism in rats through secretion of catecholamine from adrenal medulla Watanabe,T.;Kawada,T.;Iwai,K.
  3. Pharmacological Reviews v.38 The neuropharmacology of capsaicin : Review of some recent observations Buck,S.H.;Burks,T.F.
  4. Biochem. Biophys Res. Comm. v.142 Capsaicin, a pungent principle of hot pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats Watanabe,T.;Kawada,T.;Yamamoto,M.;Iwai,K.
  5. Hum. Nutr. v.40c Effect of spiced food on metabolic rate Henly,C.K.;Emery,B.
  6. Peppers (First Vintage Books Edition) Amal,N.
  7. Int. J. Immunopahrmac. v.10 Altered Lymphocyte proliferation of immunized rats after neurological manupulation with capsaicin Nilsson,G.;Ahlstedt,S.
  8. Int. J. Immunopharamac. v.13 Effect on immune responses in rats after neuromanipulation with capsaicin Nilson,G.;Alvirg,K.;Ahlstedt,S.
  9. Korean J. Immunol. v.16 Effect of capsaicin on the humoral immune response in mice Yu,R.
  10. Dietary capsaicin modulation on select immune response Yu,R.;Park,J.W.;Erickson,K.L.;Kurata,T.
  11. Eur. J. Immunol. v.2 Spontaneous B cell activation due to loss of normal mouse serum suppression Bullock,W.W.;Moller,E.
  12. New protective roles for selected nutrients Krinsky,N.I.
  13. 한국영양식량학회지 v.19 Ascorbic acid 및 김치가 다환 방향족 탄화수소 섭취 guinea pig의 생체이물대사에 미치는 영향 유리나;홍순명;최석영
  14. 한국영양학회지 v.28 시중에서 유통되고 있는 일부 국산 고추가루와 수입산 고추가루의 영양성분 및 맛 성분에 관한 비교연구 손숙미;이중희;오명숙
  15. Agric. Biol. Chem. v.49 In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper in rats Kawada,T.;Iwai,K.
  16. Indian J. Biochem. Biophys. v.26 Influence of spices and spice principles on hepatic mixed function oxygenase system in rats Sambaiah,K.;Srinivasan,K.
  17. J. Neuroimmunol. v.26 Effect of capsaicin treatment on immunoglobulin secretion in the rat Eglezos,A.;Andrews,P.V.;Boyd,R.L.;Helme,R.D.
  18. Cell. Tissue Res. v.262 Peptidergic innervation of rat lymphoid tissue and lung relation to mast cells and sensitivity to capsaicin and immunization Nilsson,G.;Alving,K.;Ahlstedt,S.;Hokfeit,T.;Lundberg,J.M.
  19. Proc. Nutr. Soc. v.50 Beta-catotene and the immune response Bendich,A.
  20. Vitamin C Ascorbic acid and immune functions Anderson,R.;Counseel,J.N.(ed.);Homig,D.H.(ed.)
  21. Korean J. Food Nutr. v.24 Antimutagenic effects of juices from the peppers in Salmonella assay system Kwon,Y.M.;Rhee,S.H.;Park,K.Y.
  22. J. Gastroenterol. Hepatol. v.7 The effect of chilli ingestion on gastrointestinal mucosal proliferation and azoxymethane induced cancer in the rat Kang,J.Y.;Alexander,B.;Baker,F.;Man,W.K.
  23. vivo v.3 Inhibitory effect of capsaicin on mouse lung tumor development Jang,J.J.;Kim,S.H.;Yun,T.K.