Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Novel Withanolides from the Flowers of Datura tatula

  • Srivastava, Anjani (Department of Medicinal Chemistry) ;
  • Manickam, M. (Department of Medicinal Chemistry) ;
  • Sinha-Bagchia, A. (Institute of Medical Sciences) ;
  • Sinhaa, S.C. (Institute of Medical Sciences) ;
  • Ray, A.B. (Banaras Hindu University)
  • Published : 1996.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Three new withanolides, designated as withatatulins B, C, and D, were isolated from the fresh flowers of Datura tatula Linn. Detailed spectral analysis of these compounds permitted advancement of their structures respectively, as $5{\beta},6{\beta}-epoxy-12{\beta}$,21-dihydroxy-1-oxo-witha-2,24-dienolide (2), $6{\beta},12{\beta},21-trihydroxy-1-oxowitha$ 2, 4,24-trienolide (3) and $5{\beta},6{\beta},12{\beta}$,21-tetrahydroxy-1-oxo-witha-2,24-dienolide (4a). Withanolides with oxygen functions both at 12 and 21-positions are rare and first reported from Datura species.

Keywords