Journal of Pharmaceutical Investigation
- Volume 26 Issue 2
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- Pages.91-98
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- 1996
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Preparation and Bioavailability of Oriental Medicine containing Baicalin (II) : Gastro-Intestinal Absorption and Antibacterial Effect of Coprecipitated Product of Scutellariae Radix and Coptidis Rhizoma
바이칼린 함유 생약의 제제화 및 생체 이용률 (제 2보) : 황금 및 황련 공침물의 장내 흡수 및 항균 효과
- Yang, Jae-Heon (College of Pharmacy, Woosuk University) ;
- Kim, Dong-Su (College of Pharmacy, Woosuk University) ;
- Yoo, Hee-Doo (College of Pharmacy, Woosuk University) ;
- Lee, Nam-Hee (College of Pharmacy, Woosuk University)
- Published : 1996.06.20
Abstract
Precipitation was formed during the preparation of decoction from a mixure of Scutellariae Radix and Coptidis Rhizoma or Phellodendri Cortex according to the prescription of Hwang-ryean-hae-dog-tang. Baicalin and berberine, the active ingredients of the two herbal medicine were identified in coprecipitated product. Pills were prepared using the coprecipitated product and various binders. The dissolution rate of baicalin and berberine from pills was increased in at pH1.2 when acacia or tragacanth was used. The absorption rate of baicalin from the coprecipitated product was faster than that from Scutellaria extract, but the absorption of berberine from CPP was slower in stomach, duodenum and jejunum of rats compared with Coptis extract. The time required for the maximum serum concentration (Cmax) of baicalin and berberine from CPP in mice were 150 and 200 min after oral administration, respectively. The maximum serum concentration of baicalin from CPP in mice was higher than Scutellaria extract, but the concentration of berberine was lower compared with Coptis extract. The minimum inhibitory concentration of CPP was below
Keywords
- Baicalin;
- Berberine;
- Coprecipitated product;
- Intestinal absorption;
- Serum concentration;
- Antib acterial activity;
- Bioavailability