Radiation Oncology Journal
- Volume 14 Issue 2
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- Pages.137-147
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- 1996
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
Prophylactic Cranial Irradiation for Acute Lymphoblastic Leukemia in Childhood
소아 급성 림프모구성 백혈병의 예방적 전뇌 방사선조사
- Kim, In-Ah (Department of Radition Oncology St. Mary's Hospital, Catholic University, Medical College) ;
- Choi, Ihl-Bhong (Department of Radition Pediatrics, St. Mary's Hospital, Catholic University, Medical College) ;
- Kang, Ki-Mun (Department of Radition Pediatrics, St. Mary's Hospital, Catholic University, Medical College) ;
- Shinn, Kyung-Sub (Department of Radition Pediatrics, St. Mary's Hospital, Catholic University, Medical College) ;
- Kim, Hack-Ki (Department of Radition Pediatrics, St. Mary's Hospital, Catholic University, Medical College)
- 김인아 (가톨릭의대 성모병원 방사선 종양학과) ;
- 최일봉 (가톨릭의대 성모병원 방사선 종양학과) ;
- 강기문 (가톨릭의대 성모병원 방사선 종양학과) ;
- 신경섭 (가톨릭의대 성모병원 방사선 종양학과) ;
- 김학기 (가톨릭의대 성모병원 소아과)
- Published : 1996.06.01
Abstract
Purpose : This report is the result f retrospective analysis for children who received prophylactic cranial irradiation combined with intrathecal chemotherapy. Materials and Methods : Ninety children with ALL who had got bone marrow remission after induction chemotherapy received PCI. All but 3 children were treated with a dose of 1800 cGy as a standard regimen. While the PCI was given, all patients received intrathecal chemotherapy. Results : Nine of 90 patients experienced CNS relapse during the duration of follow-up ranged from 36 to 96 months (median 60 months). Three children experienced BM relapse prior to CNS relapse. Therefore, CNS relapse rate as the first adverse event was
목적 : 소아 급성임파모구성 백혈병 환자에 있어 예방적 전뇌방사선조사 및 척수강내화학 요법후 중추신경계 재발율, 재발양상, 중추신경계 무병생존율, 전체무병생존율및 이에 영향을 미치는 예후인자들을 알아보고자 하였다. 대상 및 방법 : 1987년 7원부터 1992년 6월까지 예방적 전뇌 방사선조사를 받은 급성 임파구성 백혈병 환아 90예를 대상으로 후향적 분석을 시행하였다. 3명을 제외한 모든 환자들이 일일 180 cGy 씩 퐁 1800 cGy의 전뇌방사선치료를 받았고, 방사선 치료중 척수강내 화학요법이 병행되었다. 결과 : 추적관착기간 36-96 개원 (중앙값 60 개원)동안 90명의 환아중 9례에서 중추신경계 재발을 보였으나, 골수재발이 선행되었던 3례를 제외하면 중추신경계 재발율은