Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지

Effect of Acidic Polysaccharide Components of Korean Ginseng on Lipolytic Action of Toxohormone-L and on Activity of Angiotensin Converting Enzyme

고려인삼중 다당체 성분이 암독소 호르몬-L의 지방분해 작용과 안지오텐신 변환효소의 활성에 미치는 영향

  • Lee, Sung-Dong (Department of Food Nutrition, Junior College of Allied Health Sciences, Korea University) ;
  • Hwang, Woo-Ik (Department of Biochemistry, College of Medicine, Korea University) ;
  • Okuda, Hiromichi (2nd Department of Medical Biochemistry, School of Medicine, Ehiwa University)
  • 이성동 (고려대학교 보건전문대학 식품영양과) ;
  • 황우익 (고려대학교 의과대학 생화학교실) ;
  • 흥전척도 (일본 애원대학 의학부 제2생화학교실)
  • Published : 1996.12.01
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Abstract

This study was devised to observe in vitro, the inhibitory effects of acidic polysaccharide fractions from Korean red ginseng (KRG) and white ginseng (KWG) on the lipolytic action of loxohormone-L and on angiotensin converting enzyme (ACE, peptidyldipeptidase hydrolase, EC 3.4.15.1) . The crude acidic polysaccharides (CAP) extracted from main and lateral roots of KRG and KWG were separately purified through several procedures. The total inhibitory activities on the lipolytic action of toxohormone-L of CAP from main roots of KRG and KWG was higher than those of CAP from lateral roots of KRG and KWG, respectively, and that of CAP from main root of KRG was 3.1 times higher than that of CAP from main root of KWG. The specific activity of CAP from main root of KRG was measured as 5.40 units/mg, when one unit was defined as the amount giving 50% inhibition on toxohormone-L induced lipolysls. A subfraction named PG4 3 obtained by replanted chromatography on DEAE-TOYOPEARL 650M gave the specific activity of 24.4 units/mg. On the other hand, it was found that the total inhibitory activity on ACE of CAP from lateral root of KRG was the highest among the 4 kinds of CAP, but the specific activity of CAP from lateral root of KWG was the highest.

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