Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Cytotoxicity of Trichothecenes to Human Solid Tumor Cells in Vitro

  • Choi, Sang-Un (Pharmaceutical Screening Lab., Korea Research Instittute of Chemical Technology) ;
  • Choi, Eun-Jung (Pharmaceutical Screening Lab., Korea Research Instittute of Chemical Technology) ;
  • Kim, Kwang-Hee (Pharmaceutical Screening Lab., Korea Research Instittute of Chemical Technology) ;
  • Kim, Nam-Young (Pharmaceutical Screening Lab., Korea Research Instittute of Chemical Technology) ;
  • Kwon, Byung-Mog (Bioproducts Research Group, Korea Research Institute of Bioscience and Technology, KIST) ;
  • Kim, Sung-Uk (Bioproducts Research Group, Korea Research Institute of Bioscience and Technology, KIST) ;
  • Bok, Song-Hae (Bioproducts Research Group, Korea Research Institute of Bioscience and Technology, KIST) ;
  • Lee, So-Young (Bioproducts Research Group, Korea Research Institute of Bioscience and Technology, KIST) ;
  • Lee, Chong-Ock (Pharmaceutical Screening Lab, Korea Research Institute of Chemical Technology)
  • Published : 1996.02.01
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Abstract

The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin(I) and $4-\beta$-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-.betha.-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and $4-\beta$-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and $4-\beta$-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 $\mug/ml$. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

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