Archives of Pharmacal Research
- Volume 19 Issue 1
- /
- Pages.52-59
- /
- 1996
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
In vitro Activities of LB20304, a New Fluoroquinolone
- Kim, Mu-Yong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd) ;
- Oh, Jeong-In (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd) ;
- Paek, Kyoung-Sook (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd) ;
- Hong, Chang-Yong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd) ;
- Kim, In-Chull (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd) ;
- Kwak, Jin-Hwan (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd)
- Published : 1996.02.01
Abstract
The in vitro activity of LB20304 was evaluated against clinical isolates and compared with those of Q-35, ciprofloxacin, sparfloxacin, lomefloxacin and ofloxacin. LB20304 demonstrated 16-to 64-fold more potent activity than ciprofloxacin against gram-positive bacteria. LB20304 inhibited 90% of the isolates of methicillin-susceptible Staphylococcus aureus(MSSA) at a concentration of