Toxicological Research

  • 제12권1호
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  • Pages.1-8
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  • 1996
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Dimethylformamide가 사람 혈청의 과산화지질 농도와 Superoxide dismutase 활성도 변화에 미치는 영향

Effects of Dimethylformamide on Lipid Peroxide Level and Activity of Superoxide Dismutase in Human Serum

  • 김기웅 (한국산업안전공단 산업보건연구원) ;
  • 최정근 (한국산업안전공단 산업보건연구원) ;
  • 김태균 (한국산업안전공단 산업보건연구원) ;
  • 송문기 (한국산업안전공단 산업보건연구원) ;
  • 고경선 (한국산업안전공단 산업보건연구원) ;
  • 손남석 (한국산업안전공단 산업보건연구원) ;
  • 조영숙 (한국산업안전공단 산업보건연구원) ;
  • 김소연 (한국산업안전공단 산업보건연구원) ;
  • 김희곤 (한국산업안전공단 산업보건연구원)
  • 발행 : 1996.06.01
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초록

The variation in the enzyme activities of human liver usually represents the particular physiological conditions of each individuals. Thus, we investigated the variation in the activities of SOD, HR and LPO of (1) non-exposed workers (56 subjects), and (2) exposed workers to DMF (43 subjects) in synthetic leather process. Serum levels of enzyme activities of exposed workers (AST:$30.26{\pm}20.041$U/L, ALT:$32.72{\pm}23.393$U/L, GGT:$28.47{\pm}18.635$ U/L, ALP:$81.77{\pm}34.879$ U/L)were slightly higher than those in nonexposed workers (AST:$24.00{\pm}9.441$ U/L, ALT:$23.89{\pm}18.305$U/L, GGT:$21.95{\pm}17.970$U/L, ALP:$70.84{\pm}24.678$U/L), but only the level of ALT was statistically significant (p< 0.05). Serum levels of LDH, TRF and CHOL in non-exposed workers were slightly higher than those of exposed workers. However, they were not statistically significant (p > 0.05). Serum levels of HR and LPO of the exposed workers appeared to be reduced, but not those of the non-exposed workers. The SOD activities of exposed workers were also slightly higher than those of non-exposed workers, but the results were not statistically significant (p > 0.05). The level of HR was increased with age, but the SOD level was not. These results suggest that the intermittent exposure to DMF at time-weighted average (TWA) level (10 ppm/$m^3$) has affected on the activities of enzymes such as AST, ALT, TRF, but not on the generation of HR, activity of SOD. However, if high dose of DMF was used, there would be severe effects for the generation of HR and LPO.

키워드

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