Toxicological Research

  • 제12권1호
  • /
  • Pages.93-99
  • /
  • 1996
  • /
  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

새로운 반합성 Rifamucin 유도체 KTC-1의 랫트 수태능력 시험

Fertility Study of KTC-1, a New Semisynthetic Rifamycin Derivative, in Rats.

  • 김종춘 (한국화학연구소 안전성연구센터) ;
  • 정문구 (한국화학연구소 안전성연구센터) ;
  • 노정구 (한국화학연구소 안전성연구센터)
  • 발행 : 1996.06.01
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초록

The effect of KTC-1, a new semisynthetic rifamycin antituberculous drug, on general toxicity, reproductive capability and fetal development was investigated in Sprague-Dawley rats. Male rats were administered KTC-1 with mashed feed from 63 days before mating to the end of mating period, and female rats were given from 14 days before mating to day 7 of gestation at dose levels of 0, 375, 750, and 1,500 ppm. The females were sacrificed on day 21 of gestation for examination of their fetuses. At 1,500 ppm, a reduction in body weight gain and testis atrophy were observed in male rats. Histological examination revealed testicular atrophy, absence or decrease of germinal cells, and vacuolization of Sertoli cells in testis. A reduction in body weight gain, a decrease in food consumption were found in female rats. In addition, decreases in the number of corpora lutea, iraplantations, and the litter size of live fetuses were seen. Mating, fertility, and pregnancy performances were also affected. There were no external abnormalities observed by examination of fetuses. At 750 ppm, a reduction in the body weight gain of male and female rats and decreases in the number of implantations and litter size were found. At 375 ppm, no treatment-related effects were observed. The results suggest that the no-effect dose levels (NOELs) of KTC-1 are 375 ppm for males and females on general toxicity, 750 ppm for males and females on reproductive capability, and 375 ppm for fetuses on embryonic development.

키워드

참고문헌

  1. J. of Antibiot. v.34 Antibacterial activity of DL 473, a new semisynthetic rifamycin derivative Arioli,V.;Berti,M.;Carniti,G.;Randisi,E.;Rossi,E.;Scotti,R.
  2. Testis and epididymis in Pathology of the Fischer rats Boorman,G.A.;Chapin,R.E.;Mitsumori,K.;Boorman,G.A.(ed.)
  3. Science v.200 Rifampicin inhibition of protein synthesis in mammalian cells Buss,W.C.;Morgan,R.;Guttmann,J.;Barela,T.;Stalter,K.
  4. Antibiotiki v.22 Pharmacology of rifampicin Bykova,M.A.;Solov'ev,V.N.;Berezhinskaia,V.V.;Egorenko,G.G.;Firsov,A.A.
  5. Male reproductive system in Handbook of toxicologic pathology Creasy,D.M.;Foster,P.M.D.;Haschek,W.M.(ed.)
  6. Drugs v.23 Adverse effects of antituberculosis drugs Girling,D.J.
  7. Toxicol. Appl. Pharmacol. v.69 Enhancement of rifampin teratogenicity in cultured rat embryos Greenaway,J.C.;Fantel,A.G.
  8. Teratology v.10 Investigations on the mode of teratogenic actionof of high doses of rifampicin Jager,E.;Merker,H.J.;Bass,R.
  9. Drug Metab. Rev. v.12 no.1 Metabolism and pharmacokinetics of the antibiotic rifampin Kenny,M.T.;Strates,B.
  10. Chemotherapia v.11 Rifampicin, a new orally active rifamycin Maggi,N.(et al.)
  11. Test methods for assessing female reproductive and developmental toxicology in Principles and methods of toxicology (3rd ed.) Manson,J.M.;Kang,Y.J.;Hayes,A.W.(ed.)
  12. Critical phases of intrauterine development in Basic Concepts in Teratology Persaud,T.V.N.;Persaud,T.V.N.(ed.)
  13. Martindale: The extra pharmacopoeia(Thirtieth Edition) Reynolds,J.E.F.;Parfitt,K.;Parsons,A.V.;Sweetman,S.C.
  14. Praeger monographs in infectious disease v.2 Tuberculosis Schlossberg,D.
  15. Lancet v.2 Rifampicin in pregnancy Steen,J.S.M.;Stainton-Ellis,D.M.
  16. Ann. Intern. Med. v.116 Rifampicin-associated ulcerative colitis Tajima,A.(et al.)
  17. Toxicity test guideline: Collection of notifications related to the pharmaceutical affairs laws(IV) Yakugyo Jiho Co
  18. Postgrad. Med. J. v.66 Rifampicin-induced upper gastrointestinal bleeding Zargar,S.A.(et al.)
  19. A risk assessment approach in Principles and methods of toxicology(3rd ed.) Assessment of male reproductive toxicity Zenick,H.;Clegg,E.D.;Perreault,S.D.;Klinefelter,G.R.;Gray,L.E.;Hayes,A.W.(ed.)
  20. 한국독성학회지 v.11 no.1 새로운 반합성 Rifamycin 유도체 KTC-1의 랫트 최기형 시험 김종춘;정문구;박종일;한상섭
  21. 한국독성학회지 v.11 no.1 새로운 반합성 Rifamycin 유도체 KTC-1의 랫트 주산기 및 수유기 시험 김종춘;정문구;한상섭;노정구
  22. 화학물질의 안전성평가연구(V): 랫트에 있어서 KTC-1의 13주간 아급 성독성 시험 김형진
  23. 화학물질의 안전성평가연구(VII): 랫트에 있어서 KTC-1의 52주간 만성 독성 시험 김형진