Effects of Aluminum Compounds on Kidney Metabolism and Plasma Hormone of Rats

알루미늄 화합물이 흰쥐의 신장대사 및 혈장 Hormone에 미치는 영향

  • 한성희 (원광대학교 생명자원과학대학) ;
  • 김중만 (원광대학교 생명자원과학대학) ;
  • 백승화 (원광대학교 생명자원과학대학) ;
  • 이호섭 (원광대학교 한의학과) ;
  • 박성수 (원광대학교 생명자원과학대학)
  • Published : 1996.02.01


The study was performed to investigate the effects of administration of aluminum compound in Kidney metabolism and plasma hormone of rats. Seventy frve male Sprague-Dawley strains rats were divided into five groups consisting of the control, 250ppm AlCl$_3$group, 500ppm AlCl$_3$ group, 250ppm $Al_2$(SO$_4$)$_3$group, 500ppm $Al_2$(SO$_4$)$_3$group and kept on the diet for 2 weeks. The body weight gain was increased by the administration of AlCl$_3$ but decreased by the administration of $Al_2$(SO$_4$)$_3$as compared to the control. The urinary excretion of sodium and creatinine were increased and free water clearance and urine volume were decreased significantly after AlCl$_3$adminstration group as compared to the control. The water balance, free water clearance, excretion of sodium and creatinine were increased and the excretion of chlorine was decreased after $Al_2$(SO$_4$)$_3$ administration as compared to the control. Plasma renin activity was increased and plasma aldosterone content was compared to the control. Plasma renin activity was increased and plasma aldosterone content was significantly decreased after adminstration of aluminum compounds as compared to the control.


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