Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Dietary Fiber and Large Bowel Cancer

  • Published : 1996.06.01
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Abstract

Large bowel cancer correlates tightly to dietary factors such as dietary fiber and fat. Dietary fiber prevents the large bowel cancer in different modes of action which depend upon physicochemical and fermentable properties. Water-soluble fiber is fermented easily by intestinal microbes producing short chain fatty acids ; in contrast, water-insoluble fiber occurs effectively more rapid transit time due to greater bulk of gut content, though it is unfermentable. Not only short chain fatty acid is utilized in the proximal and distal colon as primary energy source, but also it lowers pH in the colon to normalize cellular differentiation and helps to stimulate peri staltic movement by acting as an osmotic laxative. In particular, butyric acid may also regulate gene expression and cell growth, though it is an important respiratory fuel for the colonocyte. Since dietary fiber and non-digestible oligosaccharides are the major source of butyric acid, this provides a possible link between dietary fiber and oligosaccharide and prevention of large bowel cancer. But, as with many links between dietary fiber and large bowel cancer, a direct casual association has not been established. In addition, RDA of dietary fiber which is 20~25g/day for adult Japanese, appears to be reasonable for the defecation once daily and the prevention of large bowel cancer.

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References

  1. Cancer mortality statistics in the world Kirihara, M.;Aoki, K.;Hisamichi, O.
  2. Diet, nutrition and cancer Multiethnic studies of diet, nutrition and cancer in Hawaii Kolonel, L. N.;Hankin, J. H.;Nomura, A. M. Y.;Hayashi, Y.(et al.)(eds.)
  3. Reports of the national nutrition survey for Japanese in 1993, Daiichi-Shuppan The Ministry of Health and Welfare
  4. Healthiest no.98 Dietary fiber prevents colonic cancer Tsuji, K.
  5. Dietary fiber, fiber-depleted foods and diseases Cancer of the large bowel Cummings, J.;Trowell, H.(ed.);Burkitt, D.(ed.);Heaton, K.(ed.)
  6. J. Nutr. v.122 Utilization and excretion of a new sweetener fructooligosaccharides(Neosugar) in rats Tokunage, T.;Oku, T.;Hosoya, N.
  7. Unconventional sources of dietary fiber Some in vitro and in vivo properties of dietary fibers from noncereal sources Van Soest, P.;Horvath, P.;McBurney, M.;Jeraci, J.;Allen, M.;Furda, I.(ed.)
  8. Topics dietary fiber research Fermentation as the principal cause of the physiological activity of ingestible food residue Hellendoorn, E. W.;Spiller, G. A.(ed.);Amen, R. J.(ed.)
  9. Gastroenterology v.83 Utilization of nutrients by isolated epithelial cells of the rat colon Roediger, A.;W.E.W.
  10. Carcinogenesis v.7 n-Butyrate alters chromatin accessibility to DNA repair enzymes Smith, P. J.
  11. Cell v.12 Effect of n-butyrate on DNA synthesis in chick fibroblasts and Hela cells Hagopian, H. K.;Riggs, M. G.;Swartz, L. A.;Ingram, V. M.
  12. Gastoenterology v.91 Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rate intestinal neoplasia Freeman, H. J.
  13. Am. J. Physiol. v.246 Effect of dietary fiber on rat large bowel mucosal growth and cell proliferation Jacobs, L. R.;Lupton, J. R.
  14. J. Nutr. v.118 Long-term effects of fermentable fibers on rat colonic pH and epithelial cell cycle Lupton, J. R.;Coder, D. M.;Jacobs, L. R.
  15. Br. J. Nutr. v.58 Stimulatory effect of short-chain fatty acids on epi­thelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors Sakata, T.
  16. Br. J. Nutr. v.56 Differing effect of pectin, cellulose and lignin on stool pH, transit time and weight Hillman, L.;Peters, S.;Fisher, A.;Pomare, E. W.
  17. Am. J. Clin. Nutr. v.31 Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects, and bowel cancer patients MacDonald, I. A.;Webb, G. R.;Mhony, D. E.
  18. J. Roy. Soc. Med. v.75 Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology Malhotra, S. L.
  19. Exp. Cell Res. v.7 Differentiated mammary gland tumour tissue grown in an alkaline medium in vitro Pikovski, M. A.
  20. Acta Path. Micro. Scand. v.72 Parameters in 7-@-dehydroxylation of bile acids by anaerobic lactobacilli Midtvedt, T.;Norman, A.
  21. Lancet v.2 Breath methane in patients with cancer of the large bowel Haines, A.;Metz, G.;Dilawari, J.;Blendis, L.;Wiggins, H.
  22. Gastroenterology v.87 Methane production and colon cancer Pique, J. M.;Pallares, M.;Cuso, E.;Vilar-Blendis, L.;Gassull, M. A.
  23. J. Jpn. Soc. Nutr. Food Sci. v.34 Effect of various unavailable carbohydrates and administrating periods on several physiological functions of rats Oku, T.;Konishi, F.;Hosoya, H.
  24. J. Nutr. Sci. Vitaminol. v.30 Hypertrophic effect of unavailable carbohydrate on cecum and colon in rats Konishi, F.;Oku, T.;Hosoya, N.
  25. Nutr. Res. v.15 Reversible cecal and colonic enlargement induced by dietary fiber in rats Oku, T.
  26. Br. J. Nutr. v.51 Effects of addition of kaolin or cellulose to an elemental diet on intestinal cell proliferation in the colon of rats Goodlad, R. A.;Wright, N. A.
  27. Pflugers Arch. v.372 Nucleic acid and protein content of rat cecum mucosa in dietary adaptation-growth by cellular hyperplasia Loeschke, K.;Resch, W.
  28. Effects of lactosucrose on colonic cancer and colonic environment in rats Katayama, Y.
  29. Recommended dietary allowances for Japanese(5th revision) The Ministry of Health and Welfare
  30. Standard tables of food composition in Japan-Dietary fiber- Resources Council, Science and Technology Agency, Japan
  31. J. Accoc. Off. Anal. Chem. v.71 Determination of insoluble, soluble, and total dietary fiber in foods and food products : Interlaboratory study Prosky, L.;Asp, N. G.;Schweizer, T. F.;Devries, J. W.;Furda, I.
  32. J. Nutr. Sci. Vitaminol. v.37 Fecal output, gastrointestinal transit time, frequency of evacuation and apparent excretion rate of dietary fiber in young men given diets containing different levels of dietary fiber Saito, T.;Hayakawa, T.;Nakamua, K.;Inmami, S.
  33. J. Jpn. Soc. Gastroenterology v.86 Examination of fecal weight and effect of cellulose ingestion in patients with constipation Nakaji, S.;Murakami, H.;Tamura, K.;Iwane, S.;Fukuda, S.;Ohta, M.;Munakata, A.;Yoshida, Y.
  34. J. Jpn. Soc. Gastroenterology v.82 Examination of dietary fiber intake in patients of colon cancer Ohta, M.;Ishiguro, M.;Iwane, S.;Nakaji, S.;Sano, M.;Tsuchida, S.;Aizawa, N.;Yoshida, Y.
  35. Am. J. Clin. Nutr. v.30 Can fecal weight be used to establish a recommended intake of dietary fiber (plantix) Spiller, G. A.;Chernoff, M. C.;Shipley, E. A.;Beigler. M. A.;Briggs, G. M.
  36. Gastroenterology v.103 Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber) Cummings, J. H.;Bingham, S. A.;Heaton, K. W.;Eastwood, N. A.
  37. Physiological effects and health consequences of dietary fiber Pilch, S. M.
  38. Jpn. J. Nutr. v.53 Comparison of two dietary fiber tables published by Science and Technology Agency Japan and Japan Association of Prefectural and Manucipal Public Health Institutes Oku, T.;Okazaki, M.;Konishi, S.
  39. Report on license of Food for Specified Health Uses The Ministry of Health and Welfare