Journal of Nutrition and Health

  • 제29권7호
  • /
  • Pages.758-771
  • /
  • 1996
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

한국여성의 Vitamin D 상태 및 관련 생화학적 변인에 관한 연구

Vitamin D Status and Related Biochemical Parameters of Women in Korean

  • 문수재 (연세대학교 생활과학대학 식품영양학과)
  • 발행 : 1996.09.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study attempted to define reference data for the distribution of vitamin d status and to explore the relationship between vitamin D status and related biochemical indices in Korean women. The vitamin D status of 179 Korean women aged from 20 to 75 years was analyzed by using HPLC(High Pressure Liquid Chromatography). Related biochemical indices such as iPTH, alkaline phosphatase, creatinine, albumin, Ca, Mg and P were also measured. The mean serum level of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were s25.8ng/ml and 89.8pg/ml, respectively. Low 25-hydroxyvitamin D (<25nmol/L) was found in 29 subjects(16.5%). There was a significantly progressive decrease in serum 25-hydroxyvitamin D with increasing age(p<0.05). After in their, there was a dramatical reduction in 25-hydroxyvitamin D(p<0.05). It was also significant in post-menopasusal women compared with pre-menopausal women(p<0.000). Serum alkaline phosphatase levels increased significantly with age(p<0.001). Whereas serum calcium and phosphorus levels remained constant with age. Serum 250-hydroxyvitamin D was invesely related to iPTH (p<0.05) and alkaline phophatase (p<0.001).

키워드

참고문헌

  1. Lancet v.345 no.14 Vitamin D Fraser,D.R.
  2. J Pharm Scienc v.71 no.2 Vitamin D : An update Koshy,K.T.
  3. Lancet v.1 The Physiological economy of vitamin D Fraser,D.R.
  4. Am J Clin Nutr v.60 Vitamin D-newhorizons for the 21st century Holick,N.F.
  5. J Pediatr v.91 no.6 Measurement of 24,25-dihydroxy- vitamin D in sera of neonates and children Weisman,Y.;Reiter,E.;Root,A.
  6. Br J Med v.305 no.1 Bone density and 25-hydroxyvitamin D concentration in middle aged women Khaw,K.T.;Sney,M.J.;Compston,J.
  7. Lancet v.1 Vitamin D status in long-stay geriatric patients Corless,D.;Beer,M.;Boucher,B.J.;Gupta,S.P.;Cohen,R.D.
  8. Am J Clin Nutr v.45 Vitamin D status in the elderly : seasonal substrate deficiency cause 1,25OH₂D deficiency Bouillion,R.A.;Auwerx,J.H.
  9. J Gerontol v.38 Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol Chapuy,M.C.;Durr,F.;Chapuy,P.
  10. J Clin Invest v.64 Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients Gallagher,J.C.;Riggs,B.L.;Eisman,J.;Hamstra,A.;Arnaud,S.B.;DeLuca,H.F.
  11. Am J Clin Nutr Hypovitaminosis D and elevated serum alkaline phosphatase in elderly Irish people Mckenna,M.J.;Freaney,R.;Meade,A.;Muldowrey,F.P.
  12. J Clin Invest v.76 Aging decrease the capacity of human skin to produce vitamin D Machaughlin,J.;Holick,M.F.
  13. J Clin Endocrinol Metab v.71 Vitamin D status and related parameters in a healthy population : The effects of age, sex, and season Sherman,S.S.;Hollis,B.W.;Tobin,J.D.
  14. N Engl J Med v.300 Increases in immunoreactive parathyroid hormone with age Wiske,P.S.;Epstein,S.;Bell,N.H.;Queener,S.F.;Edmondson,J.;Johnston Jr C.C.
  15. Br Med J v.5 Plasma 25-hydroxyvitamin D concentrations in patients with fractures on the femoral neck Baker,M.R.;McDonnell,H.
  16. J Nutr v.121 Magnesium absorption : Mechanisms and influence of vitamin D, calcium, and phosphate Hardwick,L.L.;Jones,M.R.;Brautbar,N.;Lee,D.B.N.
  17. Am J Clin Nutr v.52 Vitamin D supple-mentation in elderly nursing home residents increases 25-hydroxy-vitaminm D but not 1,25-dyhydroxtvitamin D Himmelstein,S.;Clemens,T.L.;Rubin,A.;Lindsay,R.
  18. Br Med J v.2 Vtamin D supplements and 25-hydroxy- vitamin D concentrations in the elderly MacLennan Hamiltom J.C.
  19. J Clin Endocrinol Metab v.38 A rapid assay for 25-OH-vitamin D without preparative chromatography Belsey,R.E.;DeLuca,H.F.;Potts,J.T.
  20. J Lab Clin Med v.91 no.5 Importance of the isolation of 25-hydroxyvitamin D before assay Dorantes,L.M.;Arnaud,S.B.;Arnaud,C.D.
  21. Clin Chem v.24 no.2 Assay of vitamin D₂and D₃and 25-hydroxyvitamin D₂and D₃in human plasma by high-performance liquid chromatography Jones,G.
  22. Arch Biochem and Biophys v.176 A sensitive, precise and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma Eisman,J.A.;Hamstra,A.J.;Kream,B.F.;DeLuca,H.F.
  23. Med Biol v.57 Simultaneous measurement of serum 25-hydroxycholecalciferol and 25-hydroxyergocalciferol Delvin,E.E.;Glorieux,H.F.;Dussault,M.;Bourbonnais,R.;Watters,G.
  24. Nature v.244 Natural and synthetic sources of circulating 25-hydroxyvitamin D in man Haddad,J.G.;Hahn,T.J.
  25. Scand J Clin Lab Invest v.52 A simplified HPLC method for determination of vitamin D, 25-hydroxyvitamin D₂and 25-hydroxyvitamin D₃in human serum Askness
  26. Lancet v.20 Metabolites of vitamin D in human vitamin D-defeciency : Effect of vitamin D or 1,25-dihydroxycholecalciferol Papapoulos,E.E.;Clemens,T.L.;Fraher,L.J.;Gleed,J.
  27. Am J Clin Nutr v.56 Serum 25-hydroxyvitamin D : Distribution and determinants in the Swiss population Bernard,B.;Sloutskis,D.;Gianoli,F.;Cornuz,J.;Rickenbach,M.;Paccaud,F.;Bunckhardt,P.
  28. Am J Clin Nutr v.46 Ca and vitamin D supplement : effect on Ca metbolism in elderly people Chapuy,M.C.;Chaupy Paul Meurier P.J.
  29. Am J Clin Nutr v.58 Age-dependent vitamn Dand vertebral condition of white women living in Curacao as campared with their counterparts in the Netherlands Doubbleman,R.;Jonxis,J.H.P.
  30. Am J Clin Nutr v.36 Nutrition status in a healthy elderly population: vitamin D Omdahl,J.C.;Garry,P.J.
  31. Br Med J v.1 Diet, sunlight ,and 25-hydroxy vitamin D in healthy children and adults Poskitt,E.M.E.;Cole,T.J.;Lawson,D.E.M.
  32. J Clin Endocrinol Metab v.72 Calcium,Vitamin D and parathyroid hormone status in young white and black women : Association with racial differences in bone mass Meier,D.E.;Luckey,M.M.;Wallenstein,S.;Clemens,T.L.;Orwoll,E.S.;Waslien,C.I.
  33. Clin Endocrinol v.36 Age-related changes in bone density, serum parathyroid hormone, calcium absorption and other indices of bone metabolism in Chinese women Chan,E.L.P.;Lau,E.;Shek,C.C.;MacDonald,D.;Woo,J.;Leung,P.C.;Swamlnathan
  34. Am J Clin Nutr v.38 Sunlight and vitamin D status in normal Saudi subjects Sedrani,S.H.;Elidrissy,A.W.T.H.;Arabi,K.M.E.
  35. J Am Geriatr Soc v.41 Exogenous calciferol adn vitamin D endocrine status and elderly nursing home residents in N.Y.city area O'Dowd,K.J.;Clemens,T.L.
  36. Am J Clin Nutr v.48 Vitamin D nutritional status and related biochemical indices in an autonomous elderly population Delvin,E.E.;Inbach,A.;Copti,M.
  37. J Intern Med v.234 Effects of age, sex, season and diet on serum ionized calcium,parathyroid hormone and vitamin D in a random population Rudnicki,M.;Thode,J.;jorgensen,T.;Heitmann,B.;Sorensen,O.H.
  38. J Clin Endocrinol Metab v.63 Alterations in calcium,vitamin D, and parathyroid hormone physiology in normal men with aging : Relationship to the development of senile osteopenia Orwoll,E.;Meier,D.E.
  39. J Clin Endocrinol Metab v.65 Age-related changes in serum immunoreactive parathyroid hormone and its biological action in healthy men and women Endres,D.B.;Morgan,C.H.;Garry,P.J.;Omdahl,J.L.
  40. Am J Clin Nutr v.32 Plasma 1, 25- dihydroxyvitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans Wilz,D.R.;Gray,R.W.;Dominguez,J.H.;Lemann,J.