Journal of Microbiology and Biotechnology
- Volume 6 Issue 4
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- Pages.245-249
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- 1996
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Structure Determination and Biological Activities of Elaiophylin Produced by Streptomyces sp. MCY-846
- LEE, SANG-YONG (Department of Microbiology, College of Natural Sciences, Kyungpook National University) ;
- MI-SOON KIM (KRIBB, KIST) ;
- HANG-SUB KIM (KRIBB, KIST) ;
- YOUNG-HO KIM (KRIBB, KIST) ;
- SOON-DUCK HONG (Department of Microbiology, College of Natural Sciences, Kyungpook National University) ;
- JUNG-JOON LEE (KRIBB, KIST)
- Published : 1996.08.01
Abstract
A cytotoxic compound, 8461 was isolated from the culture of Streptomyces sp. strain MCY846 by its cytotoxicity against gastric cancer cell line SNU-l. The IR, UV and NMR spectra of 8461 were identical to those of elaiophylin. This compound showed moderate cytotoxicity against several cell lines and exerted strong inhibitory effect on the synthesis of nitric oxide in the lipopolysaccharide stimulated-Raw 264.7 cells.