The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 30 Issue 4
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- Pages.507-515
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- 1996
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- 1225-6714(pISSN)
Effects of Potassium-Channel Opener on Thallium-201 Kinetics: In-vitro Study in Rat Myocyte Preparations and In-vivo Mice Biodistribution Study
K-통로개방제가 배양심근세포와 생쥐 체내의 Thallium-201역동학에 미치는 영향
- Lee, Jae-Tae (Department of Nuclear Medicine, School of Medicine, Kyungpook Ntional University) ;
- Kim, Eun-Ji (Department of Nuclear Medicine, School of Medicine, Kyungpook Ntional University) ;
- Ahn, Byeong-Cheol (Department of Nuclear Medicine, School of Medicine, Kyungpook Ntional University) ;
- Sohn, Kang-Kyun (Department of Nuclear Medicine, School of Medicine, Kyungpook Ntional University) ;
- Lee, Kyu-Bo (Department of Nuclear Medicine, School of Medicine, Kyungpook Ntional University) ;
- Ha, Jeoung-Hee (Department of Pharmacology, Youngnam University Medical School) ;
- Kim, Chun-K. (Mt. Sinai School of Medicine, New York)
- 이재태 (경북의대 핵의학교실) ;
- 김은지 (경북의대 핵의학교실) ;
- 안병철 (경북의대 핵의학교실) ;
- 손상균 (경북의대 핵의학교실) ;
- 이규보 (경북의대 핵의학교실) ;
- 하정희 (영남의대 약리학교실) ;
- 김천기 (Mt. Sinai의대 핵의학과)
- Published : 1996.12.20
Abstract
Background : Potassium channel opener (K-opener) opens ATP-sensitive K'-channel located at cell membrane and induces potassium efflux from cytosol, resulting in intracellular hyperpolarization. Newly synthesized K-opener is currently examined for pharmacologic potency by means of rubidium release test from smooth muscle strip pre-incubated with Rb-86. Since in-vivo behavior of thallium is similar to that of rubidium, we hypothesized that K-opener can alter T1-201 kinetics in vivo. Purpose : This study was prepared to investigate the effects of pinacidil (one of potent K-openers) on the T1-201 uptake and clearance in cultured myocyte, and in-vivo biodistribution in mice. Methods : Spontaneous contracting myocytes were prepared to imitate in-vivo condition from 20 hearts of 3-5 days old Sprague-Dawley rat and cultured for 3-5 days before use (
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