Coxiella burnetii감염과 가와사끼병과의 관련성에 관한 연구

The Association of Kawasaki Disease and Coxiella burnetii

  • 김종욱 (연세대학교 원주의과대학 소아과학교실) ;
  • 이해용 (연세대학교 원주의과대학 소아과학교실) ;
  • 이원영 (연세대학교 의과대학 미생물학교실)
  • Kim, Jong Wook (Department of Pediatrics, Wonju College of Medicine, Yonsei University) ;
  • Lee, Hae Yong (Department of Pediatrics, Wonju College of Medicine, Yonsei University) ;
  • Lee, Won Young (Department of Microbiology, College of Medicine, Yonsei University)
  • 발행 : 1996.11.20

초록

Purpose : Coxiella burnetii is a well-known causative agent of granuolmatous inflammation and an inducer of morphological change and transformation of human B lymphocyte in vitro. Coxiella burnetii manifests with several clinical symptoms depending upon the organs that are involved. We therefore undertook to clarify the association of Kawasaki disease and Coxiella burnetii. Subjects and Methods : The patient's sera were tested for antibodies specific for Coxiella burnetii, using indirect fluorescent antibody technique(IFA). We compared Coxiella burnetii infection with 3 groups of patients, group 1 (Kawasaki disease), group 2 (other febrile disease) and group 3 (control group). Results : 1) In children with Kawasaki disease (group 1), 93% of the patient tested positive for Coxiella burnetii. 2) In group 2 children, 20% of the patient tested positive for Coxiella burnetii. 3) In group 3 children, 10% of the patient tested positive for Coxiella burnetii 4) There were significant higher positive rate for Coxiella burnetii in Kawasaki disease than group 2 and group 3 (p<0.05). Conclusions : We concluded that our cases of Kawasaki disease were associated with Coxiella burnetii infection. Further studies will be needed to understand the precise role of Coxiella infection in Kawasaki disease.

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