Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

EFFECT OF NERVE GROWTH FACTOR IN REGENERATION OF MANDIBULAR NERVE OF RABBIT

가토 하치조신경 재생에 있어 Nerve Growth Factor의 효과

  • Park, Kwang (Department of Oral & Maxillofacial Surgery, Kangju Veterans Hospital) ;
  • Kim, Hyun-Tae (Department of Oral & Maxillofacial Surgery, Uijongbu St. Mary's Hospital, Catholic University Medical College) ;
  • Lee, Jong-Ho (Department of Oral & Maxillofacial Surgery, Seoul National University)
  • 박광 (광주보훈병원 구강악안면외과) ;
  • 김현태 (가톨릭의과대학부속 의정부 성모병원 치과 / 구강악안면외과) ;
  • 이종호 (서울대학교치과대학 구강악안면외과학교실)
  • Published : 1996.06.30
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Abstract

An experimental study was performed to evaluate the efficacy of nerve growth factor(NGF) on inferior alveolar nerve in a rabbit model. In 20 New Zealand white rabbits, 14mm of bilat eral alveolar nerve were resected and the defects were repaired with the 17mm silicone conduits. In group I, 5mm autologous nerve segment were located centrally in the left side after tubulization and NGF solution(Sigma chemical 0.1 mg/mL) was instilled into each conduit. In group II, nerve repair modality was the same but no NGF solution was instilled into the conduits. On 2 months and 6 months postoperatively, the results were evaluated by clinical and hist omorphometric assessment. The result was that autologous nerve segment group show the best nerve regeneration effect and NGF instilled group the worst.

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