Journal of Periodontal and Implant Science
- Volume 26 Issue 2
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- Pages.414-428
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- 1996
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
The Effect of the Basic Fibroblast Growth Factor on Proliferation Rate of the Human Periodontal Ligament Cells and Human Gingival Fibroblasts
치주인대세포 및 치은섬유아세포의 DNA 합성능에 대한 b-Fibroblast growth factor의 영향
- Cho, Young-Joon (Department of Periodontology, College of Dentistry, Kyungpook National University) ;
- Lee, Jae-Mok (Department of Periodontology, College of Dentistry, Kyungpook National University) ;
- Suh, Jo-Young (Department of Periodontology, College of Dentistry, Kyungpook National University)
- Published : 1996.06.30
Abstract
The use of basic fibroblast growth factor which function as potent biologic mediators regulating numerous activities of wound healing has been suggested for the promotion of periodontal regeneration. The mitogenic effects of basic fibroblast growth factor on human periodontal ligament cells and human gingival fibroblasts were evaluated by determining the incorporation of 5-Bromo-2'deoxy-uridine into DNA of the cells in a dose -dependent manner. The cells which were prepared were the primary cultured gingival fibroblasts and periodontal ligament cells from human the fourth or sixth subpassages were used in the experiments. The cells which were seeded DMEM contain 10% FBS. The added concentrations of basic fibroblast growth factor were 0.1, 1, 10, 50,
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