대한수의학회지 (Korean Journal of Veterinary Research)
- 제36권1호
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- Pages.209-219
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- 1996
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Guinea pig에서 alcohol과 paraquat에 의한 갑상선 독성에 미치는 selenium의 방어 효과
Protective effect of selenium on alcohol and/or paraquat-induced thyroid toxicity in guinea pigs
- Kim, Jin-sang (College of Veterinary Medicine, Chungbuk National University) ;
- Kang, Hyung-sub (College of Veterinary Medicine, Chungbuk National University)
- 투고 : 1995.09.21
- 발행 : 1996.03.25
초록
This study examined the effect of alcohol(AL) and/or paraquat(PQ) on serum TSH, thyroid hormones and enzyme activities, and the protective effect of selenium(SE) againse alcohol and/or paraquat-induced thyroid toxicity in guinea pigs. The experomental group consisted of control, 15% alcohol(AL), 4ppm sodium selentite(SE), 200ppm paraquat(PQ), AL+PQ, AL+SE, PQ+SE and AL+PQ+SE mixed in drinking water-fed guinea pigs for 4 weeks. The morphological changes of thyroid gland were studies on paraffin-embedded sections stained with H-E stain. Body weight losses, high serum concentration in TSH and cholesterol, and low values on triiodothyronine(