EFFECTS OF PALMIJIHWANGTANGS ON HYPOTHYROIDISM IN RATS INDUCED BY THIOURACIL

팔미지황탕(八味地黃湯)이 Thiouracil로 유발(誘發)한 흰쥐의 갑상선기능저하증(甲狀腺機能低下症)에 미치는 영향(影響)

In order to determine the effects of Palmijihwangtangs on the hypothyroidism, the biochemical and morphologic effects of PALMIJIHWANGTANGS against 2-thiouracil-induced hypothyroidism in rats were examined. 1. Serum $T_3$ value was significantly incresed by the treatment with PALMIJIHWANGTANG-1, 2 and 3(p<0.05). 2. Serum $T_4$ value was significantly higher in PALMIJIHWANGTANG-1 and PALMIJIIIWANGTANG-2 treated groups than that of control group. In PALMIJIHWANGTANG-3 treated group, serum $T_4$ level was significantly higher and that of control group(p<0.01). 3. Scrum free $T_4$ value was significantly incresed in the PALMIJIHWANGTANG-1 and PALMIJIHWANGTANG-2 treated groups(p<0.05) 4. Total cholesterols was significantly decresed by the treatment with PALMIJIHWANGTANG-1(p<0.05). 5. The treament with the PALMIJIHWANGTANG-1, 2 and 3 resulted in the significantly decrease of serum ALT(p<0.05). 6. Thyroid gland weight was significantly increased in PALMIJIHWANGTANG-3 treated group(p<0.01). 7. Treatment with PALMIJIHWANGTANG-1, 2 and 3 effectively recovered the dystropy and degeneration of follicle in thyroid gland caused by 2-thiouracil. 8. There was no histological and functional lesion observed in the liver after treatment with PALMIJIHWANGTANG-1, 2 and 3. These results suggest that PALMIJIHWANGTANG may be effective in the treatment of hypothyroidism.