팔미지황탕(八味地黃湯)이 Thiouracil로 유발(誘發)한 흰쥐의 갑상선기능저하증(甲狀腺機能低下症)에 미치는 영향(影響)

EFFECTS OF PALMIJIHWANGTANGS ON HYPOTHYROIDISM IN RATS INDUCED BY THIOURACIL

  • 민경훈 (대전대학교 한의과대학 내과학교실) ;
  • 김철중 (대전대학교 한의과대학 내과학교실)
  • 발행 : 1996.08.25

초록

In order to determine the effects of Palmijihwangtangs on the hypothyroidism, the biochemical and morphologic effects of PALMIJIHWANGTANGS against 2-thiouracil-induced hypothyroidism in rats were examined. 1. Serum $T_3$ value was significantly incresed by the treatment with PALMIJIHWANGTANG-1, 2 and 3(p<0.05). 2. Serum $T_4$ value was significantly higher in PALMIJIHWANGTANG-1 and PALMIJIIIWANGTANG-2 treated groups than that of control group. In PALMIJIHWANGTANG-3 treated group, serum $T_4$ level was significantly higher and that of control group(p<0.01). 3. Scrum free $T_4$ value was significantly incresed in the PALMIJIHWANGTANG-1 and PALMIJIHWANGTANG-2 treated groups(p<0.05) 4. Total cholesterols was significantly decresed by the treatment with PALMIJIHWANGTANG-1(p<0.05). 5. The treament with the PALMIJIHWANGTANG-1, 2 and 3 resulted in the significantly decrease of serum ALT(p<0.05). 6. Thyroid gland weight was significantly increased in PALMIJIHWANGTANG-3 treated group(p<0.01). 7. Treatment with PALMIJIHWANGTANG-1, 2 and 3 effectively recovered the dystropy and degeneration of follicle in thyroid gland caused by 2-thiouracil. 8. There was no histological and functional lesion observed in the liver after treatment with PALMIJIHWANGTANG-1, 2 and 3. These results suggest that PALMIJIHWANGTANG may be effective in the treatment of hypothyroidism.

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