The Journal of Dong Guk Oriental Medicine (동국한의학연구소논문집)

Research Institute of Oriental Medicine (동국대학교 한의학연구소)
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Effects of Angelicae gigantis Radix Aqua-acupuncture at Ganshu(BL18) and Qimen(LR14) on Liver Damage induced by Acetaminophen in Rats

간수, 기문혈의 당귀 약침자극이 acetaminophen으로 유발된 흰쥐의 손상간에 미치는 영향

  • Park, Gyong-Mi (Dept. of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Moon, Jin-Young (Dept. of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Ahn, Joon-Ghul (Dept. of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Choi, Mi-Jung (Dept. of Pharmacology, College of Medicine, Dongguk University) ;
  • Nam, Kyung-Soo (Dept. of Pharmacology, College of Medicine, Dongguk University) ;
  • Lim, Jong-Kook (Dept. of AM-Pointology, College of Oriental Medicine, Dongguk University)
  • 박경미 (동국대학교 한의과대학 경혈학교실) ;
  • 문진영 (동국대학교 한의과대학 경혈학교실) ;
  • 안준철 (동국대학교 한의과대학 경혈학교실) ;
  • 최미정 (동국대학교 의과대학 약리학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실)
  • Published : 1996.12.20
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Abstract

This study was done in order to investigate the protective effects of A.G.R.(Angelicae gigantis Radix) aqua-acupuncture on acetaminophen induced liver damage in rats. The liver damage was induced by acetaminophen (500mg/kg) injection into the peritoneum. The A.G.R. aqua-acupuncture solution was injected into the corresponding loci to Ganshu($BL_{18}$) and Qimen($LR_{14}$) of human body and a blank locus of the root of tail on four consecutive times at 0, 3, 6, and 12 hours after acetaminophen injection. And the serum GOT, GPT, LDH, ALP activities, total bilirubin, direct bilirubin levels were measured in the rats. The serum GOT, GPT, LDH ALP activities and bilirubin level were decreased comparing with that of a control group in case of A.G.R. aqua-acupuncture treated group, specially Ganshu and Qimen aqua-acupuncture treated groups showed an obvious significant decrease.

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