The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Purification and properties of an antifungal component, AF-001, from Cinnamomi Cortex

계피로부터 항진균물질 AF-001의 분리.정제 및 특성

  • Bang, Kyu-Ho (Department of Microbiology, Chungnam National University,R & D Center, KOLON Pharmaceutical INC.) ;
  • Lee, Young-Ha (Department of Microbiology, Chungnam National University) ;
  • Min, Byung-Sun (R & D Center, KOLON Pharmaceutical INC.)
  • 방규호 (충남대학교 미생물학과,코오롱제약 기술연구소) ;
  • 이영하 (충남대학교 미생물학과) ;
  • 민병선 (코오롱제약 기술연구소)
  • Published : 1997.12.30
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Abstract

Ether extract of Cinnamomi Cortex showing antifungal activity was purified and characterized. The active component from the extract was identified to be trans-cinnamaldehyde, which was effective in inhibiting the growth of the representative fungi of dermatomycosis with minimum inhibitory concentration of $39{\sim}78\;{\mu}g/ml$. The antifungal spectrum of trans-cinnamaldehyde was broader than that of commercial antifungal agent, Ketoconazole.

계피의 항진균활성을 검색한 결과 에테르 추출물이 우수한 활성을 나타내는 것으로 평가되어 계피 에테르의 추출물로부터 항진균물질 AF-001을 분리 정제하였으며 이를 동정한 결과 trans-cinnamaldehyde로 확인되었다. AF-001은 피부진균증의 원인 균주인 Tricophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Cryptococcus neofomans, Aspergillus niger, Candida albicans와 Penicillium avellaneum에 대해 $38{\sim}79\;{\mu}g/ml$의 최소저지농도를 보였으며 imidazole계의 대표적인 항진균제인 Ketoconazole보다 광범위한 항균 스펙트럼을 보였다.

Keywords

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