무우자갈버섯(Hebeloma crustulineforme)을 위시한 한국산 담자균류 46종의 용혈활성 검색

A Preliminary Screening of 46 Korean Basidiomycetes Including Hebeloma crustulineforme for Their Hemolytic Activities

  • 발행 : 1997.12.30

초록

한국산 야생버섯의 독성을 규명하기 위한 연구의 일환으로 46종의 야생버섯의 용혈독성을 검색하여 다음과 같은 결과를 얻었다. 1) 46종 중 Amanita esculenta, A. griseofarinosa, A. longistriata, A. melleiceps, A. phalloides, A. rubescence, A. spissacea, A. vaginata, Hebeloma crustuliniforme, Lepiota cygnea, Macrolepiota procera, 및 Oudemansiella platyphylla 등 12종의 야생 담자균 냉침액이 마우스 적혈구에 대하여 강력한 용혈활성을 나타내었다. 2) A. griseofarinosa 및 H. crustuliniforme은 $100^{\circ}C$ 수용상에서 5분간 가열하여도 그 용혈 활성이 소실되지 않아 열에 매우 안정한 용혈성분을 함유하는 것으로 추정된다.

To elucidate the hemolytic toxicities of Korean basidiomycetes, the cold-water extracts of 46 wild mushrooms were tested for hemolytic activity on mouse erythrocytes. Twelve species including Amanita esculenta, A. griseofarinosa, A. longistriata, A. melleiceps, A. phalloides, A. rubescence, A. spissacea, A. vaginata, Hebeloma crustuliniforme, Lepiota cygnea, Macrolepiota procera, and Oudemansiella platyphylla showed strong hemolytic activities. Of these, A. griseofarinosa and H. crustuliniforme showed no decrease in their hemolytic activity even after five minutes' boiling.

키워드

참고문헌

  1. Toxicon. v.31 Toxin content, phallotoxin and amatoxin composition of Amanita phalloides tissues Enjalbert, F.;Gallion, C.;Jehl, F.;Monteil, H.
  2. Hoppe. Seylers. Z. Physiol. Chem. v.355 Isolation and toxicity of two cytolytic glycoproteins from Amanita phalloides mushrooms Faulstich, H.;Weckauf. Bloching., M.
  3. BLV Handbuch, Pilze Gerhardt, E.
  4. Colored illustrations of fungi of Japan Imazeki, R.;Hongo, T.
  5. 日本의 버섯 Imazeki, R.;Otani, Y.;Hongo, T.
  6. Kor. J. Microbiol. v.22 Studies on the toxicity of Auricularia polytricha Kim, H.W.;Choi, E.C.;Kim, B.K.
  7. Korean Mushrooms Kim, S.S.;Kim, Y.S.
  8. Annu. Rev. Pharmacol. Toxicol. v.19 Toxic fungi. Lampe, K.F.
  9. Colored Korean Mushrooms Lee, J.Y.
  10. Simon & Schuster's Guide to Mushrooms Pacioni, G.
  11. Colored illustrations of Korean fungi Park, W.H.
  12. Arch. Toxicol. v.30 Presence of hemolysins in Amanita species Seeger, R.;Kraus, H.;Wiedmann, R.
  13. Naunyn. Schmiedebergs. Arch. Phamacol. v.287 Demonstration and isolation of phallolysin, a haemolytic toxin from Amanita phalloides Seeger, R.
  14. Naunyn. Schmiedebergs. Arch. Pharmacol v.288 Some physico-chemical properties of phallolysin obstained from Amanita phalloides Seeger, R.
  15. Naunyn. Schmiedebergs. Arch. Phamacol. v.293 The Haemolytic effect of phallolysin Seeger, R.;Burkhardt, M.;Haupt, M.;Feulner, L.
  16. Naunyn. Schmiedebergs. Arch. Pharmacol. v.315 Degranulation of rat mast cells in vitro by the fungal cytolysins phallolysin, rubescenslysin and fascicularelysin Seeger, R.;Bunsen, E.
  17. Toxicon. v.19 Toxic effects in mouse and rat of rubescenslysin from Amanita rubescens Seeger, R.;Odenthal, K.P.;Mengs, U.
  18. Eur. J. Gell. Biol. v.25 The mechanism of cytolysis of erythrocytes by the mushroom toxin phallolysin. Morphological and biochemical evidence for sodium influx and swelling Seitz, J.;Adler, G.;Stofft, E.;Faulstich, H.
  19. CRC. Crit. Rev. Biochem. v.5 Amatoxins, phallolysin, and antamanide. The biologically active components of poisonous Amanita mushrooms Wieland, T.;Faulstich, H.