Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antibacterial Constituents from Scutellariae Radix against Streptococcus mutans OMZ176

충치균, Streptococcus mutans OMZ176에 대한 황금의 항균활성성분

  • Moon, Yong-Hyup (College of Pharmacy, Chungnam National University) ;
  • Lee, You-Hui (Korea Ginseng & Tobacco Research Institute) ;
  • Min, Byung-Sun (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Published : 1997.09.30
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Abstract

To develop anticariogenic agents, Scutellariae Radix was tested for its antibacterial activity against Streptococcus mutans OMZ176 which is known as a strong cariogenic bacterium. The antibacterial activity was evaluated with disk plate method and minimal inhibitory concentration (MIC). The ethyl acetate fraction showed significant activity. By means of activity-guided fractionation, baicalein and ganhuangenin were isolated as the active principles. The MICs of these compounds were $100{\mu}g/ml$ and $200{\mu}g/ml$, respectively.

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