Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Aluminum Compound on Kidney Tissues of Rats

알루미늄 화합물이 흰쥐의 신장조직에 미치는 영향

  • Han, Sung-Hee (Department of Life Science and Natural Resources, Wonkwan University) ;
  • Kim, Joong-Man (Department of Life Science and Natural Resources, Wonkwan University) ;
  • Baek, Seung-Hwa (Department of Life Science and Natural Resources, Wonkwan University) ;
  • Han, Du-Seok (Department of Oral Anatomy School of Dentistry, Wonkwang University) ;
  • Sin, Mee-Kung (Department of Food Nutrition, Wonkwang University)
  • 한성희 (원광대학교 생명자원과학대학) ;
  • 김중만 (원광대학교 생명자원과학대학) ;
  • 백승화 (원광대학교 생명자원과학대학) ;
  • 한두석 (원광대학교 치과대학) ;
  • 신미경 (원광대학교 식품영양학과)
  • Published : 1997.12.01
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Abstract

This study was performed to investigate the effects of aluminium treatment on renal damage in rats. Seventy five male Sprague-Dawley strains were divided into five groups; the control, 250 ppm $AlCl_3$, group, 500 ppm AlCl3 group, 250 ppm $Al_2(SO_4)_3$, group, 500 ppm $Al_2(SO_4)_3$ group and kept on the diet for 2 weeks. The body weight gain was more increased in $AlCl_3$, treated of rats but decreased in $Al_2(SO_4)_3$, treated rats than the control, on based in histophysiological examination, in $AlCl_3$, treated group, thyrodization of kidney tubular lumen and interstitial inflammatory cell infiltration, abscess formation were demonstrated and in $Al_2(SO_4)_3$, treated animals destruction of glomeruli and necrosis in kidney cortex by inflammatory cells were shownd. On the other hand, blue-pigmented cast was noted in tubules of $AlCl_3$ administration group whereas focal aluminium accumulation was noted at interstitial tissue in kidney of $Al_2(SO_4)_3$, administration group.

알루미늄 화합물 종류에 따라 흰쥐의 신장에 축적된 알루미늄 함량과 그로 인한 신장조직의 변화를 조사하기 위하여 S-D계 수컷 75마리를 5개 그룹 즉 대조군, 250 ppm $AlCl_3$ 500 ppm $AlCl_3$ 250 ppm $Al_2(SO_4)_3$ 500 ppm $Al_2(SO_4)_3$로 나누어 2주 동안 투여한 후 그 결과를 조사하였다 신장의 알루미늄량은 $AlCl_3$ 투여군은 $64.12{\sim}91.98\;ppm$ 이었고, $Al_2(SO_4)_3$ 투여군은 $113.58{\sim}135.49\;ppm$으로 $AlCl_3$보다 $Al_2(SO_4)_3$ 투여군에서 더 많이 축적되었다. 신장조직에서 $AlCl_3$, 투여군은 세뇨관 부위의 갑상선화와 간질세포내의 염증세포의 침윤, 수질의 세뇨관 파괴부위에 알루미늄이 침착되었고, $Al_2(SO_4)_3$ 투여군에는 피질에 심한 출혈, 사구체의 파괴 및 염증부위에서 알루미늄 침착이 관찰되었다.

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