The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Study on the Standardization of Ligustici Rhizoma and Angelicae Tenuissimae Radix including the Comparison for the Biological Activity on the Active Ingredients

Ligustici Rhizoma(고본(藁本))와 Angelica tenuissimae Radix(한국고본(韓國藁本)뿌리)의 규격화(規格化) 및 유효성분(有效成分)의 진통효과(鎭痛效果) 비교(比較)에 관한 연구(硏究)

  • 김관호 (경희대학교 한의과대학 본초학교실) ;
  • 이상인 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실) ;
  • 박호군 (한국과학기술연구원 응용과학연구부) ;
  • 이재성 (한국과학기술연구원 특성분석센터)
  • Published : 1997.04.30
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Abstract

Major separation for the active ingredients and characterization of chemical properties in conjunction with screening test on animal were performed in order to analyze and standardize Ligustici Rhizoma or Angelicae Tenuissimae Radix as an important oriental herbal medicine for antiphlogistic or an important oriental herbal medicine for antiphlogistic or an anodyne. Furthermore the structure, composition and contents of ingredients for essential oil in Angelicae Tenuissimae Radix(Suckpo, Korea) were determined by means of Ge/MS followed by screening test on Z-ligustilide(82%) known as major ingredient as well as butylidenephthalide collected by HPLC with normal phase semiprep-column. The total active ingredient in Ligustici Rhizoma from China or Angelicae Tenuissimae harvested at Choonyang(Kyungnam, Korea), Jungsun(Kangwon, Korea), Suckpo(Kyungnam Korea), Youngchun(Kyungnam, Korea) have been determined showing higher abundant for three times on the product in Korea compared to that in China. In addition, the major component in Ahgelicae Tebyussunae Radux extract was found to be Z-ligustilide(70-80%) which is very different from that in Ligustici Rhizoma senkyunolide(39%) as major species. For screening test of Ligustici Rhizoma or Angelicae Tenuissimae Radix extracts toward the target animal, the efficiency has been shown the similarity on both extracts. Taking into account the level of ingredient, the total efficiency may be three times higher on Angelicae Tenuissimae Radix in Korea compared to Ligustici Rhizoma in China. As a result of present study, it is preferable to distinguish between Ligustici Rhizoma and Angelicae Tenuissimae Radix for better usage of oriental herbal medicine because of very different composition and abundant in spite of their similar screening effect.

Keywords

References

  1. 本草學 李尙仁(外)
  2. 大韓植物圖鑑 李昌福
  3. 한국, 중국, 일본의 生藥조사 비교연구 韓大錫
  4. 생약학회지 v.20 no.1 Angelica속 생약의 정유 성분에 대한 연구(II) 김현수;지형준
  5. 생약학회지 v.2 no.2 Angelica tenuissima NAKAI 열매의 성분 유경수;김종우;육창수
  6. 本草備要解析 楊東喜
  7. 本草備要 汪昻
  8. 醫學入門 李梴
  9. 新農本草經 손성연(撰)
  10. 中華人民共和國藥典(一部) 中華人民共和國衛生部藥典委員會
  11. 本草求眞 黃宮肅
  12. Acta pharmaceutica sinica v.15 no.6 當歸和歐當歸中 Ligustilide 薄層据描測定法 張秀琴(外)
  13. 藥物分析雜誌 v.9 no.3 機種藁木屬植物揮發油化學成分的分析 黃達征(外)
  14. Acta Pharmaceutica sinica v.23 no.6 川芎根莖揮發油化學成分的分析 黃達征(外)
  15. Acta Botanica Yunnanica v.10 no.2 川芎葉精油的化學成分 黃達征(外)
  16. J. Pharmacol. v.30 A newly isolated antispasmodic-Butylidenephthalide Wun-Chang KO
  17. 原色和漢藥圖鑑 難波恒雄
  18. Shoyakugaku Zasshi v.37 no.4 庸藁木의 成分硏究 小澤貢
  19. Kokai Japan 日本國特許廳
  20. Chem. Pharm. Bull. v.38 no.4 Studies on the Antitumor Promoting Acitivity of Naturally Occurring Substances. 2, Inhibition of Tumor promother Enhanced Phospholipid Metabolism by Umbelliferous Materials Atsuko Nishino;Junko Takayasu;Akio Iwashima
  21. Japan. J. Pharmacol. v.60 no.4 Antiproliferative Effects of the Traditional Chinese medicine Shimotsu-To, Its componet Cnidium Rhizome and derived compounds on primary cultures of mouse aorta smooth:muscle cells Kobayashi Shinjiro(et al)
  22. Bot. Mag. Nakai, T.
  23. Chem. Pharm. Bull. Components of Cnidium officinale Makino occurrence of Pregnenolone, coniferyl ferulate, and Hydroxyphthalide Masaru Kobayashi;Miyuki Fujita;Hiroshi Mtsuhashi
  24. Chern. Pharm. Bull. v.6 Studies on the Constituents of Umbelliferae Plants. XV. Constituents of Cnidium officinale: Occurrence of Pregnenolone, Coniferyferulate and Hydroxyphthalides Masaru Kobayashi;Miyuri Fujita;Hiroshi Mitsuhashi
  25. Journal of Natural Products v.49 no.5 Three additional phathalide derivatives, an epoxymonomer and two dimers, from Ligusticum Wallichi Rhizomes Mourad kaouadji;Francine de Pachtere;Corinne Pouget;Albert J. Chulia
  26. Japan. J. Phrmacol. v.63 Chemical structure activity of Cnidium Rhizome Derived Phthalides for the Competence Inhibition of Proliferation in primary culture of mouse aorta smooth muscle cells Shinjiro Kobayashi(et al)
  27. Yakugaku Zasshi v.90 no.3 Gas Chromatographical Studies on Natural Volatile Oils. VIII. On the Essential Oils of Chinese Medicins Gaoben Yasuhisa, S.;Masako, O.;Akira, U.;Mitsuo, U.;Seigo, F.
  28. Chem. Pharm. Bull. v.38 no.6 Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in Ssitu Yukihiro Ozaki(et al)
  29. Brit. J. Pharmacol. v.22 Whittle, B. A.