The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effects of Samsaengyeum on the Cardiovascular System in the Experimental Animal

삼생음(三生飮)이 실험동물(實驗動物)의 심혈관계(心血管系) 및 혈류장애개선(血流障碍改善)에 미치는 효과(效果)

  • Jeon, Heui-Jun (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
  • Choi, Cheol-Won (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
  • Sin, Sun-Ho (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
  • Sung, Gang-Kyung (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
  • Mun, Byung-Sun (Dept. of Oriental Medicine Graduate School of Won Kwang University)
  • 전희준 (원광대학교 한의과대학원 순환기내과학 교실) ;
  • 최철원 (원광대학교 한의과대학원 순환기내과학 교실) ;
  • 신선호 (원광대학교 한의과대학원 순환기내과학 교실) ;
  • 성강경 (원광대학교 한의과대학원 순환기내과학 교실) ;
  • 문병순 (원광대학교 한의과대학원 순환기내과학 교실)
  • Published : 1997.04.30
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Abstract

The present experiments were designed to investigate the effects of Samsaengyeum. water extracts on the Cardiovascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurement of Mortality rate was observed for measuring the effect of Samsaengyeum water extract Samsaengyeum water extract against pulmonary thromboembolism induced by collagen the mixture(0.1me/10g, 2mg/kg B.W) plus serotonin(5mg/kg B.W) in mouse. The effect of Samsaengyeiim water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Samsaengyeum dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug reduced the fibrinogen lyses time and increased the lyses area of rat. 8. Samsaengyeum reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Samsaengyeum increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug inhibited the platelet aggregation.

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References

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