Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지

Ginseng protopanaxatriol Saponins but not Protopanaxadiol Saponins Inhibit Spontaneous Motility of Intestine

인삼의 protopanaxatriol이 아니라 protopanaxatriol이 장관운동을 저해함

  • Young-Hee Shin (College of Veterinary Medicine Chonnam National University) ;
  • Seo (College of Veterinary Medicine Chonnam National University, Korea Ginseng & Tobacco Research Institute)
  • Published : 1997.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

We investigated the effects of ginseng protopanaxadiol (PD) and protopanaxatriol (PT) saponins on the spontaneous contractility of intestine. Treatment with PD saponins showed a slight inhibition of spontaneous contraction of rabbit jejunum. In contrast, PT saponins showed much larger inhibition with dose-dependent manner in a range of 25~250 $\mu\textrm{g}$/ml. The inhibitory effect by PT saponins was not desensitized with continuous presence of PT saponins for several minutes. In addition, leu-enkephalin (1 PM) also inhibited the spontaneous contraction of rabbit jejunum but the in- hibition by leu-enkephalin was desensitized rapidly. The presence of PT saponins prevented the desenstization induced by leu-enkephalin. In conclusion, we found that PT saponins exert inhibition of spontaneous contractility of rabbit jejunum and the pattern of inhibition is different from that of opioid.

Keywords