Parasites, Hosts and Diseases
- Volume 35 Issue 4
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- Pages.245-250
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- 1997
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- 2982-5164(pISSN)
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- 1738-0006(eISSN)
Effects of Cryptosporidium muris (strain MCR) infection on gastric mucosal mast cells in mice
마우스에 있어서 쥐와 포자충 감염이 위점막 비만세포에 미치는 영향
- Lee, Jae-Gu (Department of Parasitology, School of Veterinary Medicine, Chonbuk National University) ;
- Seol, Chan-Gu (Department of Parasitology, School of Veterinary Medicine, Chonbuk National University) ;
- Kim, Hyeon-Cheol (Department of Parasitology, School of Veterinary Medicine, Chonbuk National University)
- Published : 1997.12.01
Abstract
The responses of gastric mucosal mast cells (GMMCS) to infection with coccid- ian protozoa, Clptosporinium muris, in mice were examined during primary and challenge infections. Each of three-week-old ICR SPF mice was orally inoculated with a single dose of 2 × 106 oocysts of C. muffs (strain MCR). After oocyst shedding ceased, the mice were orally challenged with a single dose of 2×106 oocysts of the same species. GMMCS reached a peak on days 20-30 postinoculation (Pl) in number, and decreased thereafter. An increase on days 20-30 post-challenge-infection (PCI) was also observed. The mice showed, on the whole, normal profiles of oocyst shedding in droppings. The number of the cells of uninfected control mice remained constant. .Tudging from the above results, it is suggested that mastocytosis correlate with expulsion of C. mans in primary infection and the defense mechanism of challenge infection.
마우스에 있어서 쥐와포자충 감염에 대한 면역기전을 해명하기 위하여 이 원충을 최초 및 도전 감염시켜 위점막 비만세포수의 동태를 관찰하였다. ICR계 SPF3주령 마우스에. 그리고 감염 내과 후 분변 내의 오오시스트 음전 후에 두 번에 걸쳐 각각