Archives of Pharmacal Research
- Volume 20 Issue 1
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- Pages.17-23
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Evaluation of the in vivo Antithrombotic, Anticoagulant and Fibrinolytic Activities of Lumbricus rubellus Earthworm Powder
- Hahn, Bum-Soo (Natural Products Research Institute,Seoul National University) ;
- Jo, You-Young (Natural Products Research Institute,Seoul National University) ;
- Yang, Kyung-Youl (Natural Products Research Institute,Seoul National University) ;
- Wu, Song-Ji (Natural Products Research Institute,Seoul National University) ;
- Pyo, Mi-Kyung (Natural Products Research Institute,Seoul National University) ;
- Yunchoi, Hye-Sook (Natural Products Research Institute,Seoul National University) ;
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Kim, Yeong-Shik
(Natural Products Research Institute,Seoul National University)
- Published : 1997.02.01
Abstract
A saline suspension of Lumbricus rubellus earthworm powder (EWP) was administered to rats (1 g/kg/day) orally for 15 days to evaluate an oral effectiveness for thrombotic disorders. Blood was drawn at 2-day interval after the administration. Several parameters for antithrombotic, anticoagulant and fibrinolytic activities were measured, including platelet aggregation, clotting time, plasmin activity and the levels of FDP (fibrin/fibrinogen degradation products), D-dimer, and t-PA antigen. It did not affect platelet aggregation induced by ADP and collagen but anticoagulant activity (aPTT and TT) was gradually increased to two-folds for the first 5 days of administration and back to normal. Fibrinolytic activity of euglobulin fraction was highest on the 11 th day after the administration. The level of FDP was elevated to be comparable to the positve control
Keywords
- Lumbricus rebellus earthworm powder;
- Antiplatelet activity;
- Anticoagualnt Activity;
- Fibrionolytic activity;
- Oral administration